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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MBD1 Antibody (clone 100B272.1.) LS‑C563
MBD1 antibody LS-C563 is an unconjugated mouse monoclonal antibody to MBD1 from human and monkey. Validated for WB.
Catalog
Size
Price
LS-C563-100
100 µg (0.5 mg/ml)
$335

Popular MBD1 Products

A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
Applications: Western blot
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Immunoperoxidase of monoclonal antibody to MBD1 on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml]
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Anti-MBD1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1545 concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Immunohistochemistry image of paraffin-embedded human kidney tissue at a dilution of 1:100
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, ELISA

Product Description

MBD1 antibody LS-C563 is an unconjugated mouse monoclonal antibody to MBD1 from human and monkey. Validated for WB.

Specifications

Target
Human MBD1
Synonyms
MBD1, CXXC3, RFT
Host
Mouse
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [100B272.1.]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (2 µg/ml)
Immunogen
MBD1 antibody was raised against this antibody was generated by immunizing mice with a synthetic peptide corresponding to amino acids 391-405 (SESEDGAGSPPPYRR) of human MBD1; GenBank no ref|NP_056671.2|. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey, Marmoset, Tamarin (100%); Gibbon (93%); Horse (87%); Panda (80%).
Specificity
There are many isoforms of human MBD1 ranging from 503 (~55kD) to 655 (~71kD) amino acids in length. Researchers are encouraged to use the provided immunogen sequence to determine if this is suitable for testing a specific isoform of interest.
Presentation
PBS, 0.02% Sodium Azide
Storage
Short term: 4°C; Long term: -70°C.
Restrictions
For research use only.
About MBD1
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Q9UIS9 NM_015846 NP_056671.2


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Images

Western blot

Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).
Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).

Western blot

Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).
Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).

Western blot

Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).
Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).

Western blot

Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).
Western blot of MBD1 in HeLa cell lysate using antibody at 2 ug/ml (lane 1) and 1 ug/ml (lane 2).

Requested From: United States
Date Requested: 10/18/2018

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