MAPKAPK3

mitogen-activated protein kinase-activated protein kinase 3

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

☰ Filters

Products

Antibodies (44)

Proteins (8)

ELISA Kits (6)

Type

Custom (3)

Over-Expression Lysate (2)

Primary (44)

Recombinant (6)

Sandwich (3)

Target

MAPKAPK3 (58)

Reactivity

Human (46)

Mouse (20)

Rat (9)

Chicken (3)

Chimpanzee (6)

Gibbon (6)

Guinea pig (3)

Horse (3)

Monkey (7)

Pig (7)

Rabbit (6)

more less

Application

IHC (17)

IHC-P (6)

WB (40)

ELISA (10)

FLISA (1)

ICC (1)

IF (5)

Peptide-ELISA (2)

Host

rabbit (42)

mouse (2)

Isotype

IgG (22)

IgG2a (1)

IgG2a,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (42)

Clone

01 (1)

2B5 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Strip Plate (5)

AP Conjugated (1)

APC (1)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (3)

Preservative Free (2)

Unconjugated (20)

more less

Epitope

C-Terminus (9)

aa129-329 (8)

aa63-90 (7)

270-350 aa, C-terminal (1)

aa1-50 (1)

aa301-350 (1)

Publications

No (58)

Sample Type

Plasma (2)

Serum (2)

Tag

GST (2)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

MAPKAPK3 Antibody (clone 2B5) LS-C133527

Antibody:

MAPKAPK3 Mouse anti-Human Monoclonal (2B5) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

MAPKAPK3 Antibody LS-C800573

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

MAPKAPK3 Antibody (C-Terminus) LS-C368671

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

MAPKAPK3 Antibody (270-350 aa, C-terminal) LS-C381804

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (270-350 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

MAPKAPK3 Antibody LS-C676019

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

MAPKAPK3 Antibody (aa63-90) LS-C164476

Antibody:

MAPKAPK3 Rabbit anti-Mouse Polyclonal (aa63-90) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

MAPKAPK3 Antibody (aa63-90) LS-C329816

Antibody:

MAPKAPK3 Rabbit anti-Mouse Polyclonal (aa63-90) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

MAPKAPK3 Antibody (aa63-90, Biotin) LS-C262641

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa63-90) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

MAPKAPK3 Antibody (aa63-90, FITC) LS-C262644

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa63-90) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

FLISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

MAPKAPK3 Antibody (aa63-90, APC) LS-C262640

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa63-90) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

MAPKAPK3 Antibody (aa63-90, Azide-free, HRP) LS-C262646

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa63-90) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

MAPKAPK3 Antibody (aa63-90, PE) LS-C262647

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa63-90) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

MAPKAPK3 Antibody (aa301-350) LS-C119080

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa301-350) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAPKAPK3 Antibody LS-C768045

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

MAPKAPK3 Antibody LS-C658799

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$386

Select

MAPKAPK3 Antibody (aa1-50) LS-C290944

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$295; 100 µl/$414

Select

MAPKAPK3 Antibody LS-C832527

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

MAPKAPK3 Antibody LS-C831015

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

MAPKAPK3 Antibody (AP) LS-C349249

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (AP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

AP Conjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

MAPKAPK3 Antibody LS-C310937

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

MAPKAPK3 Antibody (clone 01, Preservative Free) LS-C820083

Antibody:

MAPKAPK3 Mouse anti-Human Monoclonal (Preservative Free) (01) Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

MAPKAPK3 Antibody (C-Terminus) LS-C135767

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

MAPKAPK3 Antibody (C-Terminus) LS-C135768

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

MAPKAPK3 Antibody (aa129-329) LS-C314809

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal (aa129-329) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

Select

MAPKAPK3 Antibody LS-C394175

Antibody:

MAPKAPK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$386

Viewing 1-25 of 58 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.