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MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

MAP4K4 is a MSN protein kinase. The protein has a structure similar to other GCK (Group I) kinases and contains two consensus SH3 binding motifs, which have been shown to interact with the SH3 domains of the SH2/SH3 adapter protein Nck. NIK can be activated by tumor necrosis factor (TNF)-alpha. Activated NIK has been shown to activate c-Jun N-terminal kinase (JNK) and to bind and activate the plasma membrane Na-H exchanger NHE1. In NIK(-/-) mice, mesodermal and endodermal cells of the primitive streak fail to migrate to their correct location, and embryos die between embryonic day (E) 9.5 and E10.5. At least three protein isoforms have been reported.

Gene Name: mitogen-activated protein kinase kinase kinase kinase 4
Family/Subfamily: Protein Kinase , MSN
Synonyms: MAP4K4, HGK, HPK/GCK-like kinase HGK, KIAA0687, Misshapen, NIK, Nck-interacting kinase, HPK/GCK-like kinase, Ste20 group protein kinase HGK, MEKKK 4, MEKKK4, Zc1, FLH21957, MEK kinase kinase 4
Target Sequences: NM_145686 NP_663719.2 O95819

Publications (1)

1
Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans. Perreault L, Bergman BC, Hunerdosse DM, Playdon MC, Eckel RH. Obesity (Silver Spring, Md.). 2010 18:1524-31. [PubMed:20035285] [PMC:PMC3232014]

☰ Filters
Antibodies (36)
Proteins (3)
Over-Expression Lysate (2)
Primary (36)
Recombinant (1)
MAP4K4 (39)
Human (36)
Mouse (17)
Rat (3)
Bat (3)
Bovine (3)
Chicken (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (1)
Pig (3)
Rabbit (3)
Xenopus (3)
IHC (8)
IHC-P (5)
WB (29)
DB (6)
ELISA (19)
ICC (1)
IF (6)
IP (2)
Peptide-ELISA (2)
rabbit (30)
mouse (6)
Product Group
IHCPlus (2)
IgG (22)
IgG1 (5)
IgG1,k (1)
monoclonal mc (7)
polyclonal pc (29)
3C7B5 (2)
4A5 (1)
4H9E7 (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (23)
aa506-534 (7)
pSer629 (6)
aa287-336 (4)
Amino Acid: 400-500 (2)
aa550-600 (2)
380-460 aa, Internal (1)
Ala553 (1)
Arg430 (1)
aa406-455 (1)
aa850-900 (1)
aa931-947 (1)
No (39)
GST, N-terminus (1)
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Human (2)
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HEK 293 Cells (1)
Wheat Germ Extract (1)
MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K4 Rabbit anti-Human Polyclonal (aa287-336) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K4 Rabbit anti-Human Polyclonal (aa287-336) (HRP) Antibody
Xenopus, Chicken, Bovine, Rat, Rabbit, Mouse, Dog, Guinea pig, Bat, Pig, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K4 Rabbit anti-Human Polyclonal (aa287-336) (Biotin) Antibody
Xenopus, Chicken, Bovine, Rat, Rabbit, Mouse, Dog, Guinea pig, Bat, Pig, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K4 Rabbit anti-Human Polyclonal (aa287-336) (FITC) Antibody
Xenopus, Chicken, Bovine, Rat, Rabbit, Mouse, Dog, Guinea pig, Bat, Pig, Horse, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
MAP4K4 Antibody - Anti-MAP4K4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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MAP4K4 Rabbit anti-Human Polyclonal (aa931-947) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$545
MAP4K4 Antibody - Immunofluorescence analysis of A549 cells, using MEKKK 4 Antibody. The picture on the right is blocked with the synthesized peptide.
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MAP4K4 Rabbit anti-Human Polyclonal (aa406-455) Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MAP4K4 Antibody - Western blot of HGK antibody
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MAP4K4 Rabbit anti-Human Polyclonal (380-460 aa, Internal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MAP4K4 Antibody - MAP4K4 monoclonal antibody (M07), clone 4A5 Western blot of MAP4K4 expression in K-562.
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MAP4K4 Mouse anti-Human Monoclonal (4A5) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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MAP4K4 Rabbit anti-Human Monoclonal (Ala553) Antibody
Mouse, Human, Monkey
WB
Unconjugated
100 µl/$688
MAP4K4 Antibody - Western blot of HUVEC cell lysate using MEKKK 4 Antibody
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MAP4K4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
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MAP4K4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
MAP4K4 Antibody - Peptide - + Immunofluorescence analysis of A549 cells, using MEKKK 4 antibody.
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MAP4K4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
MAP4K4 Antibody - Detection of Human MAP4K4/HGK by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-MAP4K4/HGK used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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MAP4K4 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
MAP4K4 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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MAP4K4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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MAP4K4 Rabbit anti-Mouse Polyclonal (aa506-534) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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MAP4K4 Rabbit anti-Mouse Polyclonal (aa506-534) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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MAP4K4 Rabbit anti-Mouse Polyclonal (aa506-534) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
MAP4K4 Rabbit anti-Mouse Polyclonal (aa506-534) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
MAP4K4 Rabbit anti-Mouse Polyclonal (aa506-534) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
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MAP4K4 Rabbit anti-Mouse Polyclonal (aa506-534) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
MAP4K4 Antibody - Western blot of HGK (R430) pAb in extracts from HUVEC cells.
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MAP4K4 Rabbit anti-Human Polyclonal (Arg430) Antibody
Mouse, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
MAP4K4 Antibody - Western blot using MAP4K4 mouse monoclonal antibody against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
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MAP4K4 Mouse anti-Human Monoclonal (4H9E7) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
MAP4K4 Antibody - Western blot using MAP4K4 mouse monoclonal antibody against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
Select
MAP4K4 Mouse anti-Human Monoclonal (3C7B5) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$467
MAP4K4 Antibody - Western Blot (WB) analysis using HGK Monoclonal Antibody against truncated Trx-HGK recombinant protein (1), MBP-HGK (aa300-400) recombinant protein (2) and HGK(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
Select
MAP4K4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
Select
MAP4K4 Rabbit anti-Human Polyclonal (pSer629) Antibody
Human
DB, ELISA
Unconjugated
200 µl/$734
Viewing 1-25 of 39 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).