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MAP1LC3A / LC3A

microtubule-associated protein 1 light chain 3 alpha

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.

Gene Name: microtubule-associated protein 1 light chain 3 alpha
Synonyms: MAP1LC3A, ATG8E, LC3, LC3A, MAP1BLC3, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3
Target Sequences: NM_032514 NP_115903.1 Q9H492

Publications (11)

1
Pathogenic lysosomal depletion in Parkinson's disease. Dehay B, Bov J, Rodrguez-Muela N, Perier C, Recasens A, Boya P, Vila M. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 30:12535-44. (WB; Mouse, Human) [PubMed:20844148]
2
Silica nanoconstruct cellular toleration threshold in vitro. Herd HL, Malugin A, Ghandehari H. Journal of controlled release : official journal of the Controlled Release Society. 2011 153:40-8. (WB; Mouse, Human) [PubMed:21342660] [PMC:PMC3197243]
3
Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. Song D, Lee FS. The Journal of biological chemistry. 2011 286:15797-805. [PubMed:21367862] [PMC:PMC3091189] Related Antibodies: LS-C165694.
4
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15. [PubMed:21478185] Related Antibodies: LS-C165699.
5
Autophagy patterns and prognosis in uveal melanomas. Giatromanolaki AN, Charitoudis GS, Bechrakis NE, Kozobolis VP, Koukourakis MI, Foerster MH, Sivridis EL. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011 24:1036-45. [PubMed:21499230] Related Antibodies: LS-C159363.
6
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai MM. Journal of virology. 2011 85:10561-71. [PubMed:21835792] [PMC:PMC3187495] Related Antibodies: LS-C158634.
7
Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and -synuclein aggregation. Chang CF, Huang HJ, Lee HC, Hung KC, Wu RT, Lin AM. Journal of pineal research. 2012 52:312-21. (WB; Mouse) [PubMed:22212051]
8
Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes. Schwarz L, Goldbaum O, Bergmann M, Probst-Cousin S, Richter-Landsberg C. Journal of molecular neuroscience : MN. 2012 47:256-66. (IHC; Human) [PubMed:22411133]
9
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Jeong JK, Moon MH, Bae BC, Lee YJ, Seol JW, Kang HS, Kim JS, Kang SJ, Park SY. Neuroscience research. 2012 73:99-105. (WB; Human) [PubMed:22465415]
10
Macroautophagy abnormality in essential tremor. Kuo SH, Tang G, Ma K, Babij R, Cortes E, Vonsattel JP, Faust PL, Sulzer D, Louis ED. PloS one. 2012 7:e53040. (WB; Human) [PubMed:23300858] [PMC:PMC3531444]
11
Mitochondria-lysosome membrane contacts are defective in GDAP1-related Charcot-Marie-Tooth disease. Lara Cantarero , Elena Juárez-Escoto , Azahara Civera-Tregón , María Rodríguez-Sanz, Mónica Roldán, Raúl Benítez , Janet Hoenicka , Francesc Palau. The Breast : official journal of the European Society of Mastology. 2021 Jan;29:3589-3605. [Full Text Article] [PubMed:33372681] [PMC:PMC7823109] Related Antibodies: LS-C165694.
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MAP1LC3A / LC3A (175)
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MAP1LC3A / LC3A Antibody - 10X( lower panel) and 20X (upper panel) immunohistochemistry images from muscle tissue of a diseased mouse off Dox after 5 weeks on regular food. Several fibers that have autophagic vesicles throughout are visible. Data courtesy of Dr. Christy Caudill, Cincinnati Children's Hospital Medical Center.
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
200 µl/$393
MAP1LC3A / LC3A Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with Autophagy LC3 Antibody (APG8a) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MAP1LC3A / LC3A Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa89-120) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MAP1LC3A / LC3A Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MAP1LC3A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (OTI10H6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP1LC3A / LC3A Antibody - Anti-LC3 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa1-50) Antibody
Zebrafish, Mouse, Bovine, Rat, Opossum, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
MAP1LC3A / LC3A Antibody - Immunoblots of phosphorylated LC3 (phospho-LC3) in CHO cell culture. LC3 and LC3 S12A mutant vectors were transfected into CHO cells. The cell lysates were separated with SDS-PAGE and blotted with anti-phospho-LC3 S12 antibody. LC3 = microtubule-associated protein light chain-3; S12A = replacement of the amino acid position 12 serine of LC3 with alanine. WT = wild type LC3-transfected cell lysates; S12A = LC3 S12A mutant-transfected cell lysates; Empty vector = vector with no LC3 gene. Molecular size: LC3-I = 16kDa, and LC3-II = 14 kDa
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (pSer12) Antibody
Human
DB, WB
Unconjugated
400 µl/$393
MAP1LC3A / LC3A ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MAP1LC3A / LC3A Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (5G10) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
MAP1LC3A / LC3A Antibody - Anti-MAP1LC3A / LC3A antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
MAP1LC3A / LC3A Antibody - IHC of normal human brain using antibody (APG8) at 5 ug/ml.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa1-50) Antibody
Xenopus, Chicken, Pufferfish, Rat, Opossum, Bovine, Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$386
MAP1LC3A / LC3A Antibody - Fluorescent image of U251 cells stained LC3 (APG8A) antibody.U251 cells were treated with Chloroquine (50 mu M,16h), then fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated LC3 (APG8A) primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). LC3 immunoreactivity is localized to autophagic vacuoles in the cytoplasm of U251 cells.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
400 µl/$393
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (166AT1234) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
200 µl/$734
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (Biotin) (166AT1234) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (FITC) (166AT1234) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (APC) (166AT1234) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (Azide-free) (HRP) (166AT1234) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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MAP1LC3A / LC3A Mouse anti-Human Monoclonal (PE) (166AT1234) Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
MAP1LC3A / LC3A Antibody - Immunohistochemistry - Anti-MAP1LC3A Picoband antibody
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MAP1LC3A / LC3A Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µg/$331
MAP1LC3A / LC3A Antibody - LC3 Antibody - LC3 Antibody - IHC of LC3 in mouse liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
MAP1LC3A / LC3A Antibody - Immunohistochemistry: LC3I Antibody - IHC of LC3I in mouse testis using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Pig, Primate, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa74-106) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa74-106) (FITC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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MAP1LC3A / LC3A Rabbit anti-Human Polyclonal (aa74-106) (PE) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Viewing 1-25 of 175 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).