LOXL2

lysyl oxidase-like 2

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

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Antibodies (87)

ELISA Kits (11)

Proteins (11)

Type

Competitive EIA (1)

Custom (4)

Over-Expression Lysate (2)

Primary (87)

Recombinant (9)

Sandwich (6)

Target

LOXL2 (109)

Reactivity

Human (61)

Mouse (28)

Rat (27)

Bat (4)

Bovine (5)

Chicken (4)

Dog (5)

Guinea pig (4)

Horse (5)

Monkey (5)

Orangutan (3)

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Application

IHC (9)

IHC-P (7)

WB (74)

ELISA (18)

IF (1)

Peptide-ELISA (1)

SDS-PAGE (1)

Host

rabbit (76)

mouse (11)

Product Group

IHCPlus (4)

Isotype

IgG (19)

IgG1 (5)

IgG2a (2)

IgG2b (2)

IgG2b,k (1)

Clonality

monoclonal mc (11)

polyclonal pc (76)

Clone

04 (1)

15 (1)

5D2 (1)

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OTI4H3 (2)

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OTI8G5 (2)

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Epitope

aa53-160 (11)

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aa323-427 (8)

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aa544-751 (8)

aa553-761 (8)

aa589-617 (7)

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aa26-776 (4)

aa607-656 (4)

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aa454-742 (1)

aa739-770 (1)

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Publications

No (108)

Yes (1)

Sample Type

Cell Culture Supernatants (3)

Cell Lysates (3)

Plasma (6)

Serum (6)

Tissue Homogenates (4)

Tag

GST, N-terminus (1)

His (6)

His, N-Terminal (1)

His,C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (4)

Rat (2)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Low Endotoxin Level

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Biologically Active

Biologically active (1)

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IHC-plus™ LOXL2 Antibody (Internal) LS-A9350

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(5.0) Rating

(1) Publication(s)

Antibody:

LOXL2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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IHC-plus™ LOXL2 Antibody (Internal) LS-A9355

Fast Shipping

(4.0) Rating

Antibody:

LOXL2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ LOXL2 Antibody (N-Terminus) LS-A9354

Fast Shipping

(4.0) Rating

Antibody:

LOXL2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Rabbit, Dog, Bovine, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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IHC-plus™ LOXL2 Antibody (aa454-742) LS-B11395

(4.0) Rating

Antibody:

LOXL2 Rabbit anti-Human Polyclonal (aa454-742) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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LOXL2 Antibody (aa26-776) LS-C369938

Antibody:

LOXL2 Rabbit anti-Mouse Polyclonal (aa26-776) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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LOXL2 Antibody (aa26-776, Biotin) LS-C369939

Antibody:

LOXL2 Rabbit anti-Mouse Polyclonal (aa26-776) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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LOXL2 Antibody (aa26-776, FITC) LS-C369940

Antibody:

LOXL2 Rabbit anti-Mouse Polyclonal (aa26-776) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

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LOXL2 Antibody (aa152-450, clone OTI8B2) LS-C340273

Antibody:

LOXL2 Mouse anti-Human Monoclonal (aa152-450) (OTI8B2) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$434

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Mouse LOXL2 (Sandwich ELISA) ELISA Kit - LS-F17515

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human LOXL2 (Sandwich ELISA) ELISA Kit - LS-F7178

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Mouse LOXL2 (Sandwich ELISA) ELISA Kit - LS-F7478

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$854

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Rat LOXL2 (Sandwich ELISA) ELISA Kit - LS-F8037

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$893

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LOXL2 Antibody (clone 5D2) LS-C197624

Antibody:

LOXL2 Mouse anti-Human Monoclonal (5D2) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human LOXL2 (Sandwich ELISA) ELISA Kit - LS-F39947

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$795

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Mouse LOXL2 Protein (Recombinant His) (aa53-160) - LS-G15679

Source:

E. coli

Tag:

His

Molecular Weight:

13.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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LOXL2 Antibody LS-C678504

Antibody:

LOXL2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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LOXL2 Antibody (aa607-656) LS-C135321

Antibody:

LOXL2 Rabbit anti-Mouse Polyclonal (aa607-656) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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LOXL2 Antibody (aa323-427) LS-C295241

Antibody:

LOXL2 Rabbit anti-Human Polyclonal (aa323-427) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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LOXL2 Antibody (aa434-546, FITC) LS-C301843

Antibody:

LOXL2 Rabbit anti-Rat Polyclonal (aa434-546) (FITC) Antibody

Reactivity:

Rat

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$359; 200 µl/$423; 500 µl/$655; 1 ml/$816; 2 ml/$1,055; 5 ml/$1,863

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Mouse LOXL2 Protein (Recombinant His,C-terminus) (Met1-Gln776) - LS-G49203

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse Loxl2 consists 762 amino acids and predicts a molecular mass of 85.9 kDa.

Price:

100 µg/$480

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Human LOXL2 Protein (Recombinant His, N-Terminal) (aa323-427) - LS-G15677

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

12.8 kDa

Price:

10 µg/$291; 50 µg/$502; 200 µg/$1,002; 1 mg/$2,144; 5 mg/$3,501; 2 mg/$2,334

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LOXL2 Antibody LS-C803690

Antibody:

LOXL2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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LOXL2 Antibody (aa589-617) LS-C322702

Antibody:

LOXL2 Rabbit anti-Human Polyclonal (aa589-617) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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LOXL2 Antibody LS-C780260

Antibody:

LOXL2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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LOXL2 Antibody (aa152-450, clone OTI4H3) LS-C794053

Antibody:

LOXL2 Mouse anti-Human Monoclonal (aa152-450) (OTI4H3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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