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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LMNA / Lamin A+C Antibody (clone 12A‑2F5, DY650) LS‑C180721
Lamin A+C antibody LS-C180721 is a DY650-conjugated mouse monoclonal antibody to human Lamin A+C (LMNA). Validated for ELISA, ICC, IP and WB.
Catalog
Size
Price
LS-C180721-100
100 µl (1 mg/ml)
$365

Popular LMNA / Lamin A+C Products

Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2005 dilution 1:50.
Species: Mouse, Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
Anti-Lamin A/C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B119 dilution 1:100.
Species: Human, Monkey, Mouse, Rat, Dog, Hamster, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Species: Human, Mouse
Applications: IHC, IHC - Frozen, Immunofluorescence, Western blot, Immunoprecipitation
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Antibody
Species: Xenopus, Human, Mouse, Rat, Bovine
Applications: IHC, IHC - Frozen, Immunofluorescence, Western blot

Product Description

Lamin A+C antibody LS-C180721 is a DY650-conjugated mouse monoclonal antibody to human Lamin A+C (LMNA). Validated for ELISA, ICC, IP and WB.
About LMNA / Lamin A+C
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. P02545 NM_005572 NP_005563.1

LMNA Antibody, 70 kDa lamin Antibody, CDCD1 Antibody, CMD1A Antibody, EMD2 Antibody, FPLD Antibody, IDC Antibody, FPL Antibody, FPLD2 Antibody, Lamin A/C Antibody, Lamin Antibody, LFP Antibody, LMNC Antibody, LMN1 Antibody, LMNL1 Antibody, HGPS Antibody, Prelamin-A/C Antibody, PRO1 Antibody, Lamin A Antibody, Lamin A/C-like 1 Antibody, LGMD1B Antibody, CDDC Antibody, CMT2B1 Antibody, LDP1 Antibody


Specifications

Target
Human LMNA / Lamin A+C
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal [12A-2F5]
Conjugations
DyLight 650. Also available Unconjugated or conjugated with Biotin, DY488, DY550.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ICC (1:10 - 1:2000)
  • Western blot (1:1000)
  • Immunoprecipitation (1:10 - 1:500)
  • ELISA (1:100 - 1:2000)
  • (applications tested for the base form of this product only)
Immunogen
Synthetic peptide corresponding to amino acids 449-457 of human Lamin A + C [Accession#: NP_733821.1].
Specificity
Disease-associated point-mutant R453W of Lamin A + C.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
50 mM sodium borate
Storage
Store at 4°C in the dark.
Restrictions
For research use only.

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Images

Western blot

Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 9/20/2018

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