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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LMNA / Lamin A+C Antibody (aa481‑646) LS‑C357473
Note: This antibody replaces LS-C388779
Lamin A+C antibody LS-C357473 is an unconjugated rabbit polyclonal antibody to Lamin A+C (LMNA) from human, mouse and rat. Validated for ICC, IHC and WB.
Catalog
Size
Price
LS-C357473-100
100 µg (0.5 mg/ml)
$325
Description
Lamin A+C antibody LS-C357473 is an unconjugated rabbit polyclonal antibody to Lamin A+C (LMNA) from human, mouse and rat. Validated for ICC, IHC and WB.
Target
Human LMNA / Lamin A+C
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunogen affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • ICC
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
E.coli-derived human Lamin A/C recombinant protein (Position: Y481-Y646). Human Lamin A/C shares 90% and 92% amino acid (aa) sequence identity with mouse and rat Lamin A/C, respectively.
Epitope
aa481-646
Specificity
In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. .
Presentation
Lyophilized from 5 mg BSA, 0.9 mg sodium chloride, 0.2 mg sodium phosphate, 0.05 mg sodium azide
Reconstitution
200 µl Distilled water
Storage
At -20°C for 1 year. After reconstitution, at 4°C for 1 month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid freeze-thaw cycles.
Restrictions
For research use only.
About LMNA / Lamin A+C
P02545 NM_005572 NP_005563.1

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Images

Immunohistochemistry

Lamin A antibody IHC-paraffin: Rat Intestine Tissue.
Lamin A antibody IHC-paraffin: Rat Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.
Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.
Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.

Immunocytochemistry

Lamin A antibody ICC: A549 Cell.
Lamin A antibody ICC: A549 Cell.

Western blot

Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.
Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Rat Intestine Tissue.
Lamin A antibody IHC-paraffin: Rat Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.
Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.
Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.

Immunocytochemistry

Lamin A antibody ICC: A549 Cell.
Lamin A antibody ICC: A549 Cell.

Western blot

Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.
Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Rat Intestine Tissue.
Lamin A antibody IHC-paraffin: Rat Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.
Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.
Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.

Immunocytochemistry

Lamin A antibody ICC: A549 Cell.
Lamin A antibody ICC: A549 Cell.

Western blot

Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.
Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Rat Intestine Tissue.
Lamin A antibody IHC-paraffin: Rat Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.
Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.

Immunohistochemistry

Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.
Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.

Immunocytochemistry

Lamin A antibody ICC: A549 Cell.
Lamin A antibody ICC: A549 Cell.

Western blot

Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.
Lamin A antibody Western blot. All lanes: Anti Lamin A at 0.5 ug/ml. Lane 1: Human Placenta Tissue Lysate at 50 ug. Lane 2: SKOV Whole Cell Lysate at 40 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: COLO320 Whole Cell Lysate at 40 ug. Lane 5: HELA Whole Cell Lysate at 40 ug. Lane 6: 293T Whole Cell Lysate at 40 ug. Lane 7: A549 Whole Cell Lysate at 40 ug. Predicted band size: 74 kD. Observed band size: 74 kD.

Requested From: United States
Date Requested: 12/12/2018
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