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LMNA / Lamin A+C Antibody (aa455‑469) LS‑C388836
Lamin A+C antibody LS-C388836 is an unconjugated rabbit polyclonal antibody to Lamin A+C (LMNA) from human, mouse, rat and other species. Validated for ICC, IHC and WB.
Catalog
Size
Price
LS-C388836-100
100 µg (0.5 mg/ml)
Unavailable

Popular LMNA / Lamin A+C Products

Antibody
Species: Xenopus, Human, Mouse, Rat, Bovine
Applications: IHC, IHC - Frozen, Immunofluorescence, Western blot
Anti-Lamin A/C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B119 dilution 1:100.
Species: Human, Monkey, Mouse, Rat, Dog, Hamster, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2005 dilution 1:50.
Species: Mouse, Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot
Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]
Species: Human
Applications: IHC, IHC - Frozen, Immunofluorescence, Western blot, Immunoprecipitation
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry

Product Description

Lamin A+C antibody LS-C388836 is an unconjugated rabbit polyclonal antibody to Lamin A+C (LMNA) from human, mouse, rat and other species. Validated for ICC, IHC and WB.
About LMNA / Lamin A+C
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. P02545 NM_005572 NP_005563.1

LMNA Antibody, 70 kDa lamin Antibody, CDCD1 Antibody, CMD1A Antibody, EMD2 Antibody, FPLD Antibody, IDC Antibody, FPL Antibody, FPLD2 Antibody, Lamin A/C Antibody, Lamin Antibody, LFP Antibody, LMNC Antibody, LMN1 Antibody, LMNL1 Antibody, HGPS Antibody, Prelamin-A/C Antibody, PRO1 Antibody, Lamin A Antibody, Lamin A/C-like 1 Antibody, LGMD1B Antibody, CDDC Antibody, CMT2B1 Antibody, LDP1 Antibody


Specifications

Target
Human LMNA / Lamin A+C
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Predicted
Bat, Dog, Xenopus (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • ICC (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide (RNKSNEDQSMGNWQI, aa455-469 of UniProt P02545) was used as the immunogen for this Lamin A/C antibody (100% homologous in human, mouse and rat). Percent identity by BLAST analysis: Human, Mouse, Rat, Sheep, Bovine, Hamster, Elephant, Rabbit, Horse, Pig, Guinea pig (100%); Ferret, Cat, Bat, Opossum, Zebra finch, Xenopus, Dog (93%); Chicken (80%).
Epitope
aa455-469
Specificity
Human LMNA / Lamin A+C
Usage
Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The Lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Protein deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
0.2 ml Sterile distilled water
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of mouse intestine tissue
IHC-P: Lamin A/C antibody testing of mouse intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of rat intestine tissue
IHC-P: Lamin A/C antibody testing of rat intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of human lung cancer tissue
IHC-P: Lamin A/C antibody testing of human lung cancer tissue

Western blot

Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate
Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of mouse intestine tissue
IHC-P: Lamin A/C antibody testing of mouse intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of rat intestine tissue
IHC-P: Lamin A/C antibody testing of rat intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of human lung cancer tissue
IHC-P: Lamin A/C antibody testing of human lung cancer tissue

Western blot

Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate
Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of mouse intestine tissue
IHC-P: Lamin A/C antibody testing of mouse intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of rat intestine tissue
IHC-P: Lamin A/C antibody testing of rat intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of human lung cancer tissue
IHC-P: Lamin A/C antibody testing of human lung cancer tissue

Western blot

Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate
Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of mouse intestine tissue
IHC-P: Lamin A/C antibody testing of mouse intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of rat intestine tissue
IHC-P: Lamin A/C antibody testing of rat intestine tissue

Immunohistochemistry

IHC-P: Lamin A/C antibody testing of human lung cancer tissue
IHC-P: Lamin A/C antibody testing of human lung cancer tissue

Western blot

Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate
Western blot testing of Lamin A/C antibody and Lane 1: HeLa; 2: A431 cell lysate

Requested From: 
Date Requested: 7/16/2018

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