Human LF / LTF / Lactoferrin
LTF | GIG12 | Growth-inhibiting protein 12 | HLF2 | Lactotransferrin | Lactoferrin | LF | Neutrophil lactoferrin | Talalactoferrin
(tested or 100% immunogen sequence identity)
Lactoferrin purified from milk.
Recognizes human lactoferrin (LTF), an 80kD non-heme, iron-binding globular glycoprotein and member of the transferrin family present in milk and mucosal secretions, and also released from neutrophil granules during inflammation. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.