Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
BLT1 antibody LS-A1494 is an unconjugated rabbit polyclonal antibody to BLT1 (Leukotriene B4 Receptor) from human, mouse, rat and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
(applications tested for the base form of this product only)
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Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Leukotriene B4 Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Horse, Rabbit (100%); Bovine (88%); Opossum, Platypus (81%).
LS-E28294 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1494. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Human Leukotriene B4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
PBS, 0.1% Sodium Azide
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
BLT1 is a Chemoattractant Receptor that binds the potent chemoattractant leukotriene B4 (LTB4) which is involved in defense against infection. Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al., 1997). Although BLT1 shows homology to other P2Y receptors, it does not function as a purinoreceptor ( Yokomizo et al., 1997).
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Bck M, Bu DX, Brnstrm R, Sheikine Y, Yan ZQ, Hansson GK. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:17501-6. (IHC-Fr; Human)