Target
Human Leptin
Synonyms
LEP | Leptin | LEPD | Obese protein | Obese, mouse, homolog of | Obesity factor | OBS | OB
Reactivity
Human
(tested or 100% immunogen sequence identity)
Specificity
Recognizes human leptin, a 16kD hormone that plays a key role in homeostasis, in energy intake and expenditure. It is produced by fat cells and the placenta. Leptin is a well known marker for obesity; the amount of leptin in the circulation correlates with the amount of fat tissue. Lack of functional leptin and leptin receptors lead to morbid obesity. However, leptin resistance is present in almost all obese humans, meaning that obesity is not necessarily due to a decrease in leptin, but rather to a decrease in the amount of leptin that reaches and binds to the leptin receptors in the hypothalamus. Leptin has also been implicated in a number of other processes including immune function, neuroendocrine function, the adaptive response to fasting, blood pressure, bone formation, blood cell development, glucose homeostasis, fatty acid metabolism and reproductive function. May be used as a capture antibody in ELISA assays for leptin.