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| Catalog Number | Size | Price |
|---|---|---|
| LS-C499233-50 | 50 µg | $294 |
| LS-C499233-100 | 100 µg | $360 |
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Polyclonal Rabbit anti‑Human LEF1 Antibody (IHC, IF, WB) LS‑C499233
Polyclonal Rabbit anti‑Human LEF1 Antibody (IHC, IF, WB) LS‑C499233
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Specifications
Description
LEF1 antibody LS-C499233 is an unconjugated rabbit polyclonal antibody to LEF1 from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Target
Human LEF1
Synonyms
LEF1 | LEF-1 | TCF7L3 | TCF1-alpha | TCF10 | TCF1ALPHA
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant human Lymphoid enhancer-binding factor 1 protein (75-216AA)
Specificity
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Applications
- IHC
- Immunofluorescence
- Western blot
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About LEF1
Publications (0)
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Species:
Human, Mouse, Rat
Applications:
ICC, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry
Species:
Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Goat, Guinea pig, Horse, Pig, Rabbit, Chicken, Xenopus, Zebrafish
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/24/2024
Date Requested: 4/24/2024
