LATS1

large tumor suppressor kinase 1

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

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Antibodies (30)

ELISA Kits (3)

Proteins (1)

Type

Custom (1)

Primary (30)

Recombinant (1)

Sandwich (2)

Target

LATS1 (34)

Reactivity

Human (32)

Mouse (19)

Rat (14)

Bat (3)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Hamster (3)

Horse (3)

Monkey (4)

Rabbit (3)

Zebrafish (3)

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Application

IHC (10)

IHC-P (4)

WB (26)

ELISA (20)

IF (2)

IP (3)

Peptide-ELISA (1)

Host

rabbit (24)

mouse (6)

Isotype

IgG (21)

IgG2a,k (6)

Clonality

monoclonal mc (6)

polyclonal pc (24)

Format

96-Well Strip Plate (3)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (14)

Epitope

aa1-30 (7)

aa971-1020 (4)

C-Terminus (1)

aa1075-C-term (1)

aa50-100 (1)

aa521-620 (1)

Publications

No (33)

Yes (1)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

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LATS1 Antibody (aa1-30) LS-C98952

(4.1) Rating

(2) Publication(s)

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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LATS1 Antibody LS-C678477

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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LATS1 Antibody (aa50-100) LS-C287359

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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LATS1 Antibody LS-C806722

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human LATS1 (Sandwich ELISA) ELISA Kit - LS-F56350

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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LATS1 Antibody LS-C756450

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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LATS1 Antibody LS-C753905

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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LATS1 Antibody (aa1-30) LS-C322599

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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LATS1 Antibody (aa1-30, Biotin) LS-C215569

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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LATS1 Antibody (aa1-30, FITC) LS-C215570

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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LATS1 Antibody (aa1-30, APC) LS-C215568

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

LATS1 Antibody (aa1-30, Azide-free, HRP) LS-C215571

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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LATS1 Antibody (aa1-30, PE) LS-C215572

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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LATS1 Antibody LS-C782224

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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LATS1 Antibody (aa521-620) LS-C308722

Antibody:

LATS1 Mouse anti-Human Monoclonal (aa521-620) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

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LATS1 Antibody (HRP) LS-C542930

Antibody:

LATS1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

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LATS1 Antibody (Biotin) LS-C522800

Antibody:

LATS1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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LATS1 Antibody (FITC) LS-C532843

Antibody:

LATS1 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

Select

LATS1 Antibody (PE) LS-C651043

Antibody:

LATS1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

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LATS1 Antibody (APC) LS-C514584

Antibody:

LATS1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

LATS1 Antibody LS-C813582

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

LATS1 Antibody (aa1075-C-term) LS-C287363

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa1075-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

LATS1 Antibody LS-C340904

Antibody:

LATS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

LATS1 Antibody (aa971-1020) LS-C107826

Antibody:

LATS1 Rabbit anti-Human Polyclonal (aa971-1020) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

LATS1 Antibody (C-Terminus) LS-C353799

Antibody:

LATS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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