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Laminin

Laminins are high-molecular weight (~400kDa) proteins of the extracellular matrix. They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion, as well as phenotype and survival. Laminins are heterotrimeric proteins that contain an a-chain, a ß-chain, and a ?-chain, found in five, four, and three genetic variants, respectively. The laminin molecules are named according to their chain composition. Thus, laminin-511 contains a5, ß1, and ?1 chains. Fourteen other chain combinations have been identified in vivo. The trimeric proteins intersect to form a cross-like structure that can bind to other cell membrane and extracellular matrix molecules. The three shorter arms are particularly good at binding to other laminin molecules, which allows them to form sheets. The long arm is capable of binding to cells, which helps anchor organized tissue cells to the membrane.

Laminin Target Details

Target Name:

Laminin

Publications (23)

Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. McDaniel SM, Rumer KK, Biroc SL, Metz RP, Singh M, Porter W, Schedin P. The American journal of pathology. 2006 168:608-20. (WB; Rat) [PubMed:16436674] [PMC:PMC1606507]

Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration. Graham JB, Neubauer D, Xue QS, Muir D. Experimental neurology. 2007 203:185-95. (ICC; Rat) [PubMed:16970940] [PMC:PMC1851897]

VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF. Cancer research. 2009 69:4537-44. (IHC; Mouse) [PubMed:19435903] [PMC:PMC2683911]

Voluntary resistance wheel exercise during post-natal growth in rats enhances skeletal muscle satellite cell and myonuclear content at adulthood. Smith HK, Merry TL. Acta physiologica (Oxford, England). 2012 204:393-402. (ICC; Mouse) [PubMed:21854550]

Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A, Johnson MH, Alhusban A, Soliman S, Fagan SC. PloS one. 2011 6:e24551. [PubMed:21912702] [PMC:PMC3164729]

Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathy. Winkler JL, Kedees MH, Guz Y, Teitelman G. Molecular vision. 2012 18:874-86. (WB; Rat) [PubMed:22511849] [PMC:PMC3327439]

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. Mori H, Prestwich TC, Reid MA, Longo KA, Gerin I, Cawthorn WP, Susulic VS, Krishnan V, Greenfield A, Macdougald OA. The Journal of clinical investigation. 2012 122:2405-16. (WB; Mouse) [PubMed:22728933] [PMC:PMC3386832]

Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. Fernndez-Lpez D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:9588-600. (ICC, WB, IHC-Fr; Rat) [PubMed:22787045] [PMC:PMC3539825]

Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS. Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F, Mocci S, Seto P, You M, Larochelle C, Prat A, Chow S, Li L, Vandevert C, Zago W, Lorenzana C, Nishioka C, Hoffman J, Botelho R, Willits C, Tanaka K, Johnston J, Yednock T. PloS one. 2012 7:e40443. (ICC, IHC-Fr; Mouse) [PubMed:22792325] [PMC:PMC3391262]

Selective functionalization of nanofiber scaffolds to regulate salivary gland epithelial cell proliferation and polarity. Cantara SI, Soscia DA, Sequeira SJ, Jean-Gilles RP, Castracane J, Larsen M. Biomaterials. 2012 33:8372-82. (ICC; Mouse, Rat) [PubMed:22938763] [PMC:PMC3491572]

Effects of mechanical stimulation induced by compression and medium perfusion on cardiac tissue engineering. Shachar M, Benishti N, Cohen S. Biotechnology progress. 28:1551-9. (WB; Rat) [PubMed:22961835]

Morphological evaluation of the cerebral blood vessels in the late gestation fetal sheep following hypoxia in utero. Baburamani AA, Lo C, Castillo-Melendez M, Walker DW. Microvascular research. 2013 85:9-Jan. (IHC; Sheep) [PubMed:23041509]

Lack of robust satellite cell activation and muscle regeneration during the progression of Pompe disease. Schaaf GJ, van Gestel TJ, Brusse E, Verdijk RM, de Coo IF, van Doorn PA, van der Ploeg AT, Pijnappel WW. Acta neuropathologica communications. 2015 3:65. (IHC; Human) [Full Text Article] [PubMed:26510925] [PMC:PMC4625612]

Astroglial-mediated remodeling of the interhemispheric midline during telencephalic development is exclusive to eutherian mammals. Gobius I, Suárez R, Morcom L, Paolino A, Edwards TJ, Kozulin P, Richards LJ. Neural development. 2017 12:9. (IHC; Human) [Full Text Article] [PubMed:28558801] [PMC:PMC5450091]

Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. Ceasrine AM, Lin EE, Lumelsky DN, Iyer R, Kuruvilla R. eLife. 2018 October;7:pii e39689. [Full Text Article] [PubMed:30303066] [PMC:PMC6200393]

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation. Laura Morcom , Timothy J Edwards , Eric Rider, Dorothy Jones-Davis, Jonathan Wc Lim, Kok-Siong Chen, Ryan J Dean, Jens Bunt, Yunan Ye, Ilan Gobius, Rodrigo Suárez, Simone Mandelstam, Elliott H Sherr, Linda J Richards. eLife. 2021 May;10: [Full Text Article] [PubMed:33945466] [PMC:PMC8137145]

Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro. Ziad Al Tanoury, Jyoti Rao, Olivier Tassy, Bénédicte Gobert, Svetlana Gapon, Jean-Marie Garnier, Erica Wagner, Aurore Hick, Arielle Hall, Emanuela Gussoni, Olivier Pourquié. Development (Cambridge, England). 2020 June;147: [Full Text Article] [PubMed:32541004] [PMC:PMC7328153]

Wnt7a Counteracts Cancer Cachexia. Manuel Schmidt, Christine Poser, Julia von Maltzahn. Molecular therapy oncolytics. 2020 Jan;16:134-146. [Full Text Article] [PubMed:32055677] [PMC:PMC7005483]

DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation10<sup> The University of Queensland, School of Biomedical Sciences, Brisbane, Australia. Laura Morcom, Ilan Gobius, Ashley Pl Marsh , Rodrigo Suárez, Jonathan Wc Lim, Caitlin Bridges, Yunan Ye, Laura R Fenlon, Yvrick Zagar, Amelia M Douglass, Amber-Lee S Donahoo, Thomas Fothergill, Samreen Shaikh, Peter Kozulin, Timothy J Edwards , Helen M Cooper, IRC Consortium ; Elliott H Sherr, Alain Chédotal, Richard J Leventer , Paul J Lockhart , Linda J Richards. eLife. 2021 Apr;10:e61769. [Full Text Article] [PubMed:33871356] [PMC:PMC8116049]

Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats. Edwin K Jackson, Zaichuan Mi, Delbert G Gillespie, Dongmei Cheng, Stevan P Tofovic. Journal of the American Heart Association. 2021 March;10:e020088. [Full Text Article] [PubMed:33682436] [PMC:PMC8174220]

A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle. Umji Lee, Pascal Stuelsatz, Sonia Karaz, David W McKellar, Julie Russeil, Maria Deak, Iwijn De Vlaminck, Christoph Lepper, Bart Deplancke, Benjamin D Cosgrove, Jerome N Feige. iScience. 2022 July;25:104589. [Full Text Article] [PubMed:35789856] [PMC:PMC9250016]

Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies. Orlando G, Booth C, Wang Z, Totonelli G, Ross CL, Moran E, Salvatori M, Maghsoudlou P, Turmaine M, Delario G, Al-Shraideh Y, Farooq U, Farney AC, Rogers J, Iskandar SS, Burns A, Marini FC, De Coppi P, Stratta RJ, Soker S. Biomaterials. 2014 Aug;34:5915-25. [Full Text Article] [PubMed:23680364] Related Antibodies: LS-C25112.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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