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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LAMC1 / Laminin Gamma 1 Antibody (clone SPM193, Ready‑to‑Use) LS‑C390573
Laminin Gamma 1 antibody LS-C390573 is an unconjugated rat monoclonal antibody to Laminin Gamma 1 (LAMC1) from human and mouse. Validated for Flow, IF and IHC.
Catalog
Size
Price
LS-C390573-7000
7000 µl
Unavailable

Popular LAMC1 / Laminin Gamma 1 Products

Detection limit for recombinant GST tagged LAMC1 is approximately 0.3 ng/ml as a capture antibody.
Species: Human
Applications: Western blot, ELISA
Anti-LAMC1 / Laminin Gamma 1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7354 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Western blot Image
Species: Human
Applications: Western blot, ELISA
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Dog, Hamster, Horse, Pig
Applications: IHC, IHC - Paraffin, Western blot
Western blot of Laminin gamma-1 antibody
Species: Human, Monkey, Mouse, Rat
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

Laminin Gamma 1 antibody LS-C390573 is an unconjugated rat monoclonal antibody to Laminin Gamma 1 (LAMC1) from human and mouse. Validated for Flow, IF and IHC.
About LAMC1 / Laminin Gamma 1
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. P11047 NM_002293 NP_002284.3

LAMC1 Antibody, Laminin subunit gamma-1 Antibody, Laminin-7 subunit gamma Antibody, Laminin-8 subunit gamma Antibody, Laminin-1 subunit gamma Antibody, Laminin-4 subunit gamma Antibody, Laminin-9 subunit gamma Antibody, Laminin B2 chain Antibody, Laminin gamma-1 chain Antibody, Laminin-3 subunit gamma Antibody, Laminin-6 subunit gamma Antibody, S-laminin subunit gamma Antibody, Laminin Gamma 1 Antibody, Laminin-10 subunit gamma Antibody, Laminin-11 subunit gamma Antibody, Laminin-2 subunit gamma Antibody, S-LAM gamma Antibody


Specifications

Target
Mouse LAMC1 / Laminin Gamma 1
Host
Rat
Reactivity
Mouse, Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a,k Monoclonal [SPM193]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Ready-to-Use. Also available Unmodified or Azide-free.
Applications
  • IHC
  • IHC - Paraffin (1:1)
  • Immunofluorescence
  • Flow Cytometry
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Murine EHS laminin preparation.
Specificity
Mouse LAMC1 / Laminin Gamma 1
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of alpha, beta, and gamma chains. This mAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific mAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This mAb stains uniformly all human and murine basement membranes. Optimal dilution of the Laminin gamma 1 antibody should be determined by the researcher. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Presentation
PBS, 0.01% BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Laminin gamma 1 antibody (SPM193). This image was taken for the unmodified form of this product. Other forms have not been tested.

Requested From: 
Date Requested: 7/18/2018

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