KPNB1 / Importin Beta

karyopherin (importin) beta 1

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

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Products

Antibodies (29)

Proteins (9)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (29)

Recombinant (7)

Sandwich (1)

Target

KPNB1 / Importin Beta (39)

Reactivity

Human (30)

Mouse (16)

Rat (13)

Bat (4)

Bovine (4)

Chicken (3)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Horse (4)

Monkey (4)

Pig (4)

Rabbit (4)

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Application

IHC (9)

IHC-P (2)

WB (28)

Flo (1)

ELISA (2)

IP (2)

Peptide-ELISA (2)

Host

rabbit (19)

mouse (9)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (6)

IgG1 (3)

IgG2a (6)

Clonality

monoclonal mc (9)

polyclonal pc (20)

Clone

OTI10B7 (2)

OTI10D3 (2)

OTI6H3 (2)

OTI9D6 (2)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (1)

Biotin Conjugated (2)

Carrier-free (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (19)

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Epitope

aa1-200 (8)

aa21-441 (8)

aa144-193 (4)

aa190-216 (1)

aa825-C-term (1)

aa826-876 (1)

aa851-863 (1)

Publications

No (38)

Yes (1)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His, N-terminus (2)

DDK,C-terminus (1)

GST (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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IHC-plus™ KPNB1 / Importin Beta Antibody (aa851-863) LS-B2533

(4.0) Rating

Antibody:

KPNB1 / Importin Beta Goat anti-Human Polyclonal (aa851-863) Antibody

Reactivity:

Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ KPNB1 / Importin Beta Antibody (aa190-216) LS-B11745

(5.0) Rating

(1) Publication(s)

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa190-216) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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Human KPNB1 / Importin Beta Protein (Recombinant GST) (Full Length) - LS-G29141

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

123.6 kDa

Price:

10 µg/$479; 25 µg/$670

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KPNB1 / Importin Beta Antibody LS-C410144

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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KPNB1 / Importin Beta Antibody (aa826-876) LS-C288584

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa826-876) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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KPNB1 / Importin Beta Antibody LS-C666442

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI10B7) LS-C796064

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (OTI10B7) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI10B7, Carrier-free) LS-C792909

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI10B7) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI6H3) LS-C796063

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (OTI6H3) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI6H3, Carrier-free) LS-C792910

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI6H3) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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KPNB1 / Importin Beta Antibody LS-C403249

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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KPNB1 / Importin Beta Antibody (aa825-C-term) LS-C287366

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa825-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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KPNB1 / Importin Beta Antibody LS-C803466

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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KPNB1 / Importin Beta Antibody LS-C71266

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI10D3) LS-C796053

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (OTI10D3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI10D3, Carrier-free) LS-C792900

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI10D3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI9D6) LS-C796060

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (OTI9D6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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KPNB1 / Importin Beta Antibody (aa1-200, clone OTI9D6, Carrier-free) LS-C792907

Antibody:

KPNB1 / Importin Beta Mouse anti-Human Monoclonal (aa1-200) (Carrier-free) (OTI9D6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

KPNB1 / Importin Beta Antibody (aa144-193) LS-C145499

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa144-193) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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KPNB1 / Importin Beta Antibody (aa21-441) LS-C374821

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa21-441) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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KPNB1 / Importin Beta Antibody (aa21-441, HRP) LS-C713145

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa21-441) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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KPNB1 / Importin Beta Antibody (aa21-441, Biotin) LS-C688398

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa21-441) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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KPNB1 / Importin Beta Antibody (aa21-441, FITC) LS-C695346

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa21-441) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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KPNB1 / Importin Beta Antibody (aa21-441, PE) LS-C727207

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa21-441) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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KPNB1 / Importin Beta Antibody (aa21-441, Cy3) LS-C704119

Antibody:

KPNB1 / Importin Beta Rabbit anti-Human Polyclonal (aa21-441) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • Cy3

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