KPNA3 / Importin Alpha 4

karyopherin alpha 3 (importin alpha 4)

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

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Products

Antibodies (21)

Proteins (5)

Type

Over-Expression Lysate (2)

Primary (21)

Recombinant (3)

Target

KPNA3 / Importin Alpha 4 (26)

Reactivity

Human (21)

Mouse (10)

Rat (7)

Bat (1)

Bovine (1)

Chicken (1)

Chimpanzee (3)

Dog (1)

Guinea pig (3)

Hamster (2)

Horse (1)

Monkey (4)

Pig (4)

Rabbit (1)

Xenopus (3)

Zebrafish (3)

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Application

IHC (8)

IHC-P (3)

WB (20)

ELISA (1)

ICC (2)

IF (3)

IP (2)

Peptide-ELISA (2)

Host

rabbit (18)

goat (2)

rat (1)

Product Group

IHCPlus (2)

Isotype

IgG (9)

IgG2a,l (1)

Clonality

monoclonal mc (1)

polyclonal pc (20)

Clone

3D10 (1)

Format

APC (1)

APC Conjugated (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (10)

Epitope

aa3-220 (8)

N-Terminus (4)

aa1-50 (2)

C Terminus (1)

aa509-521 (1)

Publications

No (25)

Yes (1)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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IHC-plus™ KPNA3 / Importin Alpha 4 Antibody (aa509-521) LS-B2289

(5.0) Rating

(2) Publication(s)

Antibody:

KPNA3 / Importin Alpha 4 Goat anti-Human Polyclonal (aa509-521) Antibody

Reactivity:

Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ KPNA3 / Importin Alpha 4 Antibody LS-B5341

(4.0) Rating

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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KPNA3 / Importin Alpha 4 Antibody (C Terminus, Biotin) LS-C742491

Antibody:

KPNA3 / Importin Alpha 4 Goat anti-Human Polyclonal (C Terminus) (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, Peptide-ELISA, WB

Format:

Biotin Conjugated

Price:

100 µg/$503

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KPNA3 / Importin Alpha 4 Antibody (aa1-50) LS-C286559

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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KPNA3 / Importin Alpha 4 Antibody (aa1-50) LS-C288414

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$514

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KPNA3 / Importin Alpha 4 Antibody LS-C483004

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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KPNA3 / Importin Alpha 4 Antibody LS-C767806

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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KPNA3 / Importin Alpha 4 Antibody LS-C409883

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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KPNA3 / Importin Alpha 4 Antibody (clone 3D10) LS-C179426

Antibody:

KPNA3 / Importin Alpha 4 Rat anti-Mouse Monoclonal (3D10) Antibody

Reactivity:

Mouse, Rat, Hamster, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$427

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KPNA3 / Importin Alpha 4 Antibody (N-Terminus) LS-C81901

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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KPNA3 / Importin Alpha 4 Antibody (N-Terminus, HRP) LS-C458947

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Zebrafish, Rat, Pig, Mouse, Guinea pig, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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KPNA3 / Importin Alpha 4 Antibody (N-Terminus, Biotin) LS-C458945

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Zebrafish, Rat, Pig, Mouse, Guinea pig, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

KPNA3 / Importin Alpha 4 Antibody (N-Terminus, FITC) LS-C458946

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Zebrafish, Rat, Pig, Mouse, Guinea pig, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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KPNA3 / Importin Alpha 4 Antibody (aa3-220) LS-C374552

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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KPNA3 / Importin Alpha 4 Antibody (aa3-220, HRP) LS-C711646

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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KPNA3 / Importin Alpha 4 Antibody (aa3-220, Biotin) LS-C687226

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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KPNA3 / Importin Alpha 4 Antibody (aa3-220, FITC) LS-C694029

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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KPNA3 / Importin Alpha 4 Antibody (aa3-220, APC) LS-C740625

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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KPNA3 / Importin Alpha 4 Antibody (aa3-220, APC, Cy7) LS-C734653

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

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KPNA3 / Importin Alpha 4 Antibody (aa3-220, Cy3) LS-C702619

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

Select

KPNA3 / Importin Alpha 4 Antibody (aa3-220, PE) LS-C725706

Antibody:

KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• APC, Cy7
• Cy3
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • APC, Cy7
  • Cy3
  • PE

Select

Human KPNA3 / Importin Alpha 4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66014

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.6 kDa

Price:

20 µg/$1,107

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Human KPNA3 / Importin Alpha 4 Protein (Recombinant GST, N-terminus) (aa422-521) - LS-G59080

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human KPNA3 / Importin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76752

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.6 kDa

Price:

20 µg/$150

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Human KPNA3 / Importin Alpha 4 Protein (Recombinant His-T7) (aa3-220) - LS-G24941

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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