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KLKB1 / Plasma Kallikrein

kallikrein B, plasma (Fletcher factor) 1

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Gene Name: kallikrein B, plasma (Fletcher factor) 1
Family/Subfamily: Protease , Serine S1
Synonyms: KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3
Target Sequences: NM_000892 NP_000883.2 P03952

☰ Filters
Antibodies (41)
Proteins (8)
ELISA Kits (4)
Custom (2)
Over-Expression Lysate (2)
Primary (41)
Recombinant (6)
Sandwich (2)
KLKB1 / Plasma Kallikrein (53)
Human (32)
Mouse (9)
Rat (17)
Bovine (4)
Dog (6)
Gibbon (3)
Horse (6)
Monkey (4)
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IHC (9)
IHC-P (3)
WB (26)
ELISA (25)
IE (2)
IF (4)
Peptide-ELISA (2)
rabbit (36)
mouse (2)
goat (1)
rat (1)
sheep (1)
Product Group
IHCPlus (2)
IgG (32)
IgG1 (3)
monoclonal mc (3)
polyclonal pc (38)
13G11 (2)
96-Well Strip Plate (4)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (1)
Unconjugated (21)
aa508-537 (7)
C-Terminus (4)
aa429-478 (4)
310-390 aa, Internal (1)
Internal (1)
aa20-638 (1)
aa341-390 (1)
heavy chain, Cleaved-Arg390 (1)
No (53)
Plasma (2)
Serum (2)
6His, C-terminus (2)
6His, N-terminus (3)
Myc-DDK (Flag) (3)
Human (5)
Rat (2)
293T Cells (1)
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HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Yeast (2)
Purified (1)
Low endotoxin level (2)
KLKB1 / Plasma Kallikrein Antibody - Anti-KLKB1 antibody IHC of human small intestine, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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KLKB1 / Plasma Kallikrein Sheep anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
50 µg/$485
KLKB1 / Plasma Kallikrein Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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KLKB1 / Plasma Kallikrein Mouse anti-Human Monoclonal (13G11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$951; 200 µg/$1,609
KLKB1 / Plasma Kallikrein Antibody - Western blot analyses of prekallikrein and its activation products in human plasma.
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KLKB1 / Plasma Kallikrein Mouse anti-Human Monoclonal (13G11) Antibody
Human
ELISA, WB
Unconjugated
200 µg/$686
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KLKB1 / Plasma Kallikrein Goat anti-Human Polyclonal Antibody
Human, Monkey
ELISA, IE
Unconjugated
1 ml/$725
KLKB1 / Plasma Kallikrein Antibody - KLKB1 Antibody western blot of K562 cell line lysates (35 ug/lane). The KLKB1 antibody detected the KLKB1 protein (arrow).
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (aa508-537) Antibody
Human
WB
Unconjugated
400 µl/$393
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KLKB1 / Plasma Kallikrein Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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KLKB1 / Plasma Kallikrein Rabbit anti-Rat Polyclonal (HRP) Antibody
Rat
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
KLKB1 / Plasma Kallikrein Antibody - Western blot of Cleaved-Plasma Kallikrein HC (R390) antibody
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (310-390 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KLKB1 / Plasma Kallikrein Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using KLKB1 Antibody at dilution of 1:100
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
KLKB1 / Plasma Kallikrein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.469 - 30 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
KLKB1 / Plasma Kallikrein Protein
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Yeast
6His, N-terminus
29.8 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
KLKB1 / Plasma Kallikrein Antibody - Anti-KLKB1 / Plasma Kallikrein antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (aa341-390) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
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E. coli
6His, N-terminus
31.9 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
KLKB1 / Plasma Kallikrein Antibody - KLKB1 antibody Western blot of Rat Brain lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLKB1 / Plasma Kallikrein Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
WB
Unconjugated
100 µl/$424
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KLKB1 / Plasma Kallikrein Rat anti-Mouse Monoclonal (aa20-638) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$941
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (aa508-537) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (aa508-537) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
KLKB1 / Plasma Kallikrein Antibody - Fetal liver cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (aa429-478) Antibody
Human
WB
Unconjugated
100 µl/$397
KLKB1 / Plasma Kallikrein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
KLKB1 / Plasma Kallikrein Antibody - Immunohistochemical analysis of Plasma Kallikrein HC staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
KLKB1 / Plasma Kallikrein Antibody - Western blot All Lanes:Plasma kallikrein antibody at 2ug/ml Lane 1:Hela whole cell lysate Lane 2:rat brain tissue Secondary Goat polyclonal to rabbit at 1/10000 dilution Predicted band size: 71kDa Observed band size: 71kDa
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KLKB1 / Plasma Kallikrein Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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KLKB1 / Plasma Kallikrein Rabbit anti-Rat Polyclonal (HRP) Antibody
Rat
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
KLKB1 / Plasma Kallikrein Antibody - 1:100 staining human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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KLKB1 / Plasma Kallikrein Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25 of 53 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).