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KISS1R / GPR54
KISS1 receptor
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
| Gene Name: | KISS1 receptor |
| Family/Subfamily: | GPCR , Metastin |
| Synonyms: | KISS1R, AXOR12, GPR54, HOT7T175, KISS-1R, KISS1 receptor, G protein-coupled receptor 54, Metastin receptor, Rot7t175, G-protein coupled receptor 54, HH8, Hypogonadotropin-1, KiSS-1 receptor, Kisspeptins receptor |
| Target Sequences: | NM_032551 NP_115940.2 Q969F8 |
Publications (5)
1
KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model. McNally LR, Welch DR, Beck BH, Stafford LJ, Long JW, Sellers JC, Huang ZQ, Grizzle WE, Stockard CR, Nash KT, Buchsbaum DJ. Clinical & experimental metastasis. 2010 27:591-600. (Flo)
[Full Text Article]
[PubMed:20844932]
[PMC:PMC2975384]
Related Antibodies: LS-A1929.
2
The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis. Arlene J George, Bin Dong, Hannah Lail, Morgan Gomez, Yarely C Hoffiz, Christopher B Ware, Ning Fang, Anne Z Murphy, Erik Hrabovszky, Desiree Wanders, Angela M Mabb. iScience. 2022 June;25:104386. [Full Text Article]
[PubMed:35620441]
[PMC:PMC9126796]
Related Antibodies: LS-B15332.
3
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas. Chen Y, Yusenko MV, Kovacs G. The Journal of pathology. 2011 Jan;223:46-53. [Full Text Article]
[PubMed:20922711]
Related Antibodies: LS-A1929.
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(37)
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Neuroscience
KISS1R / GPR54 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
KISS1R / GPR54 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Goat, Bovine, Pig, Human
IHC, IHC-P
Unconjugated
50 µg/$440
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Fast Shipping
KISS1R / GPR54 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
KISS1R / GPR54 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
KISS1R / GPR54 Rabbit anti-Human Polyclonal (aa301-350) Antibody
Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$450
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$450
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
KISS1R / GPR54 Rabbit anti-Human Polyclonal (aa375-398) Antibody
Human
ELISA
Unconjugated
200 µg/$1,027
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
KISS1R / GPR54 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$299
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$351
KISS1R / GPR54 Rabbit anti-Human Polyclonal (270-350 aa, C-terminal) Antibody
Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$357
KISS1R / GPR54 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
KISS1R / GPR54 Rabbit anti-Rat Polyclonal Antibody
Rat
ICC, IP, WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
KISS1R / GPR54 Rabbit anti-Rat Polyclonal (HRP) Antibody
Rat
ICC, IP, WB
HRP Conjugated
100 µl/$349; 200 µl/$408; 500 µl/$609; 1 ml/$762; 2 ml/$999; 5 ml/$1,729
KISS1R / GPR54 Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat
ICC, IP, WB
Biotin Conjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
KISS1R / GPR54 Rabbit anti-Rat Polyclonal (FITC) Antibody
Rat
ICC, IP, WB
FITC Conjugated
100 µl/$359; 200 µl/$423; 500 µl/$655; 1 ml/$816; 2 ml/$1,055; 5 ml/$1,863
KISS1R / GPR54 Rabbit anti-Rat Polyclonal (PE) Antibody
Rat
ICC, IP, WB
PE Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
KISS1R / GPR54 Rabbit anti-Rat Polyclonal (Cy3) Antibody
Rat
ICC, IP, WB
Cy3 Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
KISS1R / GPR54 Rabbit anti-Mouse Polyclonal (aa375-396) Antibody
Mouse
ELISA
Unconjugated
200 µg/$1,027
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