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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-C743920-0.5 0.5 ml $665 
Antibody

Keratin, HMW + p63 Antibody LS‑C743920

Keratin, HMW + p63 Antibody LS‑C743920

Antibody:
Rabbit Monoclonal to Keratin, HMW + p63
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$665 
LS-C743920-0.5
0.5 ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Monoclonal to Keratin, HMW + p63
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Keratin, HMW + p63 antibody LS-C743920 is an unconjugated rabbit monoclonal antibody to human Keratin, HMW + p63. Validated for IHC.
Target
Keratin, HMW + p63
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG + IgG1 Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Applications
  • IHC - Paraffin (1:25 - 1:50)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant human p63 protein (aa 1-203) and cytokeratin extract of human stratum corneum
Usage
Use formalin-fixed and paraffin-embedded sections; Retrieval conditions: antigen retrieval, TEC buffer (Tris/EDTA/Citrate) pH 8 in a pressure cooker at 100°C 20-40 minutes The p63 protein, a homologue of the tumour-suppressor p53, is highly expressed in the nuclei of basal or progenitor layer of many epithelial tissues. p63 is detected in prostate basal cells in normal prostate glands and PIN. Other markers for basal cells are high molecular cytokeratins (CK 1, 5, 10 and 14), which can be labelled with HMW CK clone 34ßE12. In prostate adenocarcinoma basal cells disappear and staining with both p63 and HMW CK fails. Thus the combination of p63 and HMW CK is a useful tool as differential markers for benign prostate glands and adenocarcinoma (negative marker). nuclear p63 and cytoplasmic high molecular weight cytokeratins.
Presentation
PBS, pH 7.3, 0.09% Sodium Azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee

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Requested From: United States
Date Requested: 10/20/2019