JARID2 / JMJ

jumonji, AT rich interactive domain 2

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

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Products

Antibodies (22)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (22)

Recombinant (1)

Target

JARID2 / JMJ (25)

Reactivity

Human (21)

Mouse (15)

Rat (1)

Bovine (4)

Chicken (1)

Chimpanzee (3)

Gibbon (3)

Guinea pig (6)

Hamster (1)

Monkey (4)

Pig (7)

Rabbit (5)

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Application

IHC (1)

IHC-P (1)

WB (16)

Flo (1)

ELISA (6)

IF (1)

Peptide-ELISA (1)

Host

rabbit (19)

mouse (1)

goat (1)

sheep (1)

Isotype

IgG (10)

IgG2a (1)

Clonality

monoclonal mc (1)

polyclonal pc (21)

Clone

7H1B3 (1)

Format

Biotin Conjugated (4)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

Unconjugated (9)

Epitope

N-Terminus (4)

aa201-250 (4)

aa215-264 (4)

aa1-100 (1)

aa1-159 (1)

aa293-307 (1)

Publications

No (25)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Select

JARID2 / JMJ Antibody LS-C678391

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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JARID2 / JMJ Antibody (HRP) LS-C678395

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

JARID2 / JMJ Antibody (Biotin) LS-C678392

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

JARID2 / JMJ Antibody (FITC) LS-C678393

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

JARID2 / JMJ Antibody (aa293-307) LS-C108913

Antibody:

JARID2 / JMJ Goat anti-Human Polyclonal (aa293-307) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Hamster, Pig, Human, Monkey

Applications:

Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$401

Select

JARID2 / JMJ Antibody (clone 7H1B3) LS-C669408

Antibody:

JARID2 / JMJ Mouse anti-Human Monoclonal (7H1B3) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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JARID2 / JMJ Antibody (aa1-159) LS-C130310

Antibody:

JARID2 / JMJ Sheep anti-Human Polyclonal (aa1-159) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$930

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JARID2 / JMJ Antibody (aa201-250) LS-C116081

Antibody:

JARID2 / JMJ Rabbit anti-Mouse Polyclonal (aa201-250) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

JARID2 / JMJ Antibody (aa201-250, HRP) LS-C435413

Antibody:

JARID2 / JMJ Rabbit anti-Mouse Polyclonal (aa201-250) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Pig, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

JARID2 / JMJ Antibody (aa201-250, Biotin) LS-C435412

Antibody:

JARID2 / JMJ Rabbit anti-Mouse Polyclonal (aa201-250) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Pig, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

JARID2 / JMJ Antibody (aa201-250, FITC) LS-C435414

Antibody:

JARID2 / JMJ Rabbit anti-Mouse Polyclonal (aa201-250) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Pig, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

JARID2 / JMJ Antibody (aa1-100) LS-C49010

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (aa1-100) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

JARID2 / JMJ Antibody (N-Terminus, Biotin) LS-C140928

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

Select

JARID2 / JMJ Antibody (N-Terminus, DY650) LS-C140929

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (N-Terminus) (DY650) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

DY650 Conjugated

Price:

0.1 ml/$416

Select

JARID2 / JMJ Antibody (N-Terminus, DY488) LS-C140930

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (N-Terminus) (DY488) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

DY488 Conjugated

Price:

0.1 ml/$416

Select

JARID2 / JMJ Antibody (N-Terminus, DY550) LS-C140932

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (N-Terminus) (DY550) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

DY550 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin
• DY650
• DY488
• DY550

• Unconjugated
• Biotin
• DY650
• More...
  • DY488
  • DY550

Select

JARID2 / JMJ Antibody (aa215-264) LS-C107878

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (aa215-264) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

JARID2 / JMJ Antibody (aa215-264, HRP) LS-C465536

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

JARID2 / JMJ Antibody (aa215-264, Biotin) LS-C465534

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

JARID2 / JMJ Antibody (aa215-264, FITC) LS-C465535

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody

Reactivity:

Mouse, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

JARID2 / JMJ Antibody LS-C667853

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

JARID2 / JMJ Antibody LS-C411349

Antibody:

JARID2 / JMJ Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

Human JARID2 / JMJ Protein (Recombinant GST, N-terminus) (aa1130-1229) - LS-G59042

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human JARID2 / JMJ Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76640

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.6 kDa

Price:

20 µg/$150

Select

JARID2 / JMJ Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116280

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.6 kDa

Price:

100 µg/$494

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