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ITGB3 / Integrin Beta 3 / CD61
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
| Gene Name: | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| Family/Subfamily: | Integrin , not assigned-Integrin |
| Synonyms: | ITGB3, BDPLT2, CD61 antigen, GT, gp3A, CD61, GPIIIa, Integrin beta-3 |
| Target Sequences: | NM_000212 NP_000203.2 P05106 |
Publications (1)
1
Abnormal whole blood thrombi in humans with inherited platelet receptor defects. Castellino FJ, Liang Z, Davis PK, Balsara RD, Musunuru H, Donahue DL, Smith DL, Sandoval-Cooper MJ, Ploplis VA, Walsh M. PloS one. 2012 7:e52878.
[PubMed:23300803]
[PMC:PMC3532496]
Related Antibodies: LS-C165324.
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Fast Shipping
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Human Monoclonal (VI-PL2) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$460
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (aa752-770) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Human Monoclonal (2f2) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$310
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Pig Monoclonal (FITC) (JM2E5) Antibody
Dog, Bovine, Pig, Horse, Human
Flo
FITC Conjugated
100 µg/$962
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (aa739-788) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ITGB3 / Integrin Beta 3 / CD61 Rat anti-Mouse Monoclonal (1-55-4) Antibody
Mouse
Flo, IP, WB
Unconjugated
100 µg/$413
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
ITGB3 / Integrin Beta 3 / CD61 Hamster anti-Mouse Monoclonal (FITC) (HM beta 3.1) Antibody
Mouse
Flo
FITC Conjugated
0.1 mg/$432
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (aa734-760) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Human Monoclonal (PM6/13) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$449
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Pig Monoclonal (JM2E5) Antibody
Dog, Bovine, Pig, Horse, Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$577
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Pig Monoclonal (PE) (JM2E5) Antibody
Dog, Bovine, Pig, Horse, Human
Flo, IHC, IP, WB
PE Conjugated
100 µl/$854
ITGB3 / Integrin Beta 3 / CD61 Hamster anti-Mouse Monoclonal (2C9.G3) Antibody
Mouse, Rat
Flo, IHC, IHC-Fr
Unconjugated
500 µg/$383
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Human Monoclonal Antibody
Human
Flo, Func, WB
Unconjugated
100 µg/$832
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Pig Monoclonal (JM2E5) Antibody
Pig
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$402
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Pig Monoclonal (FITC) (JM2E5) Antibody
Pig
Flo
FITC Conjugated
0.1 mg/$642
ITGB3 / Integrin Beta 3 / CD61 Rabbit anti-Human Polyclonal (pTyr773) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Human Monoclonal (Y2/51) Antibody
Human
Flo, IHC-Fr, IHC-P
Unconjugated
0.05 mg/$460
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Rat Monoclonal (FITC) (F11) Antibody
Rat
Flo
FITC Conjugated
100 Tests/$444
ITGB3 / Integrin Beta 3 / CD61 Mouse anti-Human Monoclonal (PM6/13) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$302
E. coli
His, N-Terminal
32.9 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
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