Human IRF5

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

10T1

Unconjugated

Protein G purified

Unmodified

Recombinant human IRF5 (176-240aa) purified from E. coli.

aa176-240

Recognizes human interferon regulatory factor 5 (IRF5), a 58kD member of the IRF family which acts as a key regulator of interferon gene transcription, and is expressed in B cells and dendritic cells, and is inducible by type I interferon (IFN) in most lymphoid cells. The role of IRF3 and IRF7 as transcriptional mediators of virus- and IFN-induced signaling pathways is well documented. Studies have shown that IRF5 can also regulate IFN gene transcription, but appears to be more restricted in its cellular expression and range of viral stimuli, and has the ability to induce a wide range of chemokines involved in T-lymphocyte recruitment, including RANTES, MCP-1 and IP-10.

• IHC - Paraffin
• Western blot (1:1000 - 1:2000)
• Immunoprecipitation
• ELISA

Western Blot: LS-C45031 detects a band of approximately 58kD in THP-1 cell lysates.

PBS, 0.1% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q13568 NCBI: NM_002200 NP_116032.1