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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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IRF5 Antibody (aa176‑240) LS‑C45031
IRF5 antibody LS-C45031 is an unconjugated mouse monoclonal antibody to human IRF5. Validated for ELISA, IP and WB.
Antibody
Catalog
Size
Price
LS-C45031-100
100 µg (1 mg/ml)
Unavailable

Popular IRF5 Products

Antibody
Species: Mouse, Rat
Applications: Western blot, Immunoprecipitation, ELISA
Confocal immunofluorescence of IRF5 Antibody with A549 cell followed by Alexa Fluor 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Species: Human
Applications: Immunofluorescence, Western blot, Flow Cytometry
IRF5 antibody LS-C109630 Western blot of SH-SYSY lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit, Zebrafish
Applications: Western blot
Immunoperoxidase of monoclonal antibody to IRF5 on formalin-fixed paraffin-embedded human testis. [antibody concentration 0.8 ug/ml]
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Immunoperoxidase of monoclonal antibody to IRF5 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml]
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA

Product Description

IRF5 antibody LS-C45031 is an unconjugated mouse monoclonal antibody to human IRF5. Validated for ELISA, IP and WB.
About IRF5
IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Q13568 NM_002200 NP_116032.1

IRF5 Antibody, Interferon regulatory factor 5 Antibody, IRF-5 Antibody, SLEB10 Antibody, IBD14 Antibody


Specifications

Target
Human IRF5
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (1:1000 - 1:2000)
  • Immunoprecipitation
  • ELISA
Immunogen
IRF5 antibody was raised against recombinant human IRF5 (176-240aa) purified from E. coli.
Epitope
aa176-240
Specificity
Recognizes human interferon regulatory factor 5 (IRF5), a 58kD member of the IRF family which acts as a key regulator of interferon gene transcription, and is expressed in B cells and dendritic cells, and is inducible by type I interferon (IFN) in most lymphoid cells. The role of IRF3 and IRF7 as transcriptional mediators of virus- and IFN-induced signaling pathways is well documented. Studies have shown that IRF5 can also regulate IFN gene transcription, but appears to be more restricted in its cellular expression and range of viral stimuli, and has the ability to induce a wide range of chemokines involved in T-lymphocyte recruitment, including RANTES, MCP-1 and IP-10.
Usage
Western Blot: LS-C45031 detects a band of approximately 58kD in THP-1 cell lysates.
Presentation
PBS, pH 7.4, 0.02% Thimerosal.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/16/2018

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