INPP5D / SHIP1 / SHIP

inositol polyphosphate-5-phosphatase, 145kDa

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

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Products

Antibodies (30)

ELISA Kits (7)

Proteins (3)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Competitive EIA (2)

Custom (1)

Over-Expression Lysate (2)

Primary (30)

Recombinant (1)

Sandwich (2)

Target

INPP5D / SHIP1 / SHIP (40)

Reactivity

Human (34)

Mouse (24)

Rat (21)

Bovine (5)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Application

IHC (5)

IHC-P (4)

WB (28)

Flo (1)

ELISA (7)

ICC (1)

IF (1)

IP (1)

Peptide-ELISA (5)

Host

rabbit (29)

mouse (1)

Product Group

IHCPlus (2)

Isotype

IgG (16)

IgG2a (1)

Clonality

monoclonal mc (1)

polyclonal pc (29)

Clone

SHIP-01 (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (5)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (27)

Epitope

C-Terminus (7)

960-1040 aa (2)

N-Terminus (2)

pTyr1020 (2)

pTyr1021 (2)

1110-1190 aa, C-terminal (1)

Met1014 (1)

aa1140-1189 (1)

aa7-133 (1)

aa770-796 (1)

aa987-1036 (1)

p1020 (1)

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Publications

No (40)

Sample Type

Adherent Cell Cultures (2)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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IHC-plus™ INPP5D / SHIP1 / SHIP Antibody (N-Terminus, clone SHIP-01) LS-B13465

(4.0) Rating

Antibody:

INPP5D / SHIP1 / SHIP Mouse anti-Human Monoclonal (N-Terminus) (SHIP-01) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$545

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INPP5D / SHIP1 / SHIP Antibody (C-Terminus) LS-C145498

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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Mouse INPP5D / SHIP1 / SHIP (Competitive EIA) ELISA Kit - LS-F20238

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human INPP5D / SHIP1 / SHIP (Sandwich ELISA) ELISA Kit - LS-F39110

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$902

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INPP5D / SHIP1 / SHIP Antibody (N-Terminus) LS-C145096

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

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INPP5D / SHIP1 / SHIP Antibody LS-C767575

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$307; 120 µl/$367; 200 µl/$457

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IHC-plus™ INPP5D / SHIP1 / SHIP Antibody (aa1140-1189) LS-B11346

(4.0) Rating

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (aa1140-1189) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$505

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INPP5D / SHIP1 / SHIP Antibody LS-C662951

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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INPP5D / SHIP1 / SHIP Antibody LS-C800371

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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INPP5D / SHIP1 / SHIP Antibody LS-C782132

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1020) LS-C291632

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (pTyr1020) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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INPP5D / SHIP1 / SHIP Antibody (aa7-133, Azide-free) LS-C17828

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Mouse Polyclonal (aa7-133) (Azide-free) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated, Azide-free

Price:

200 µg/$655

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INPP5D / SHIP1 / SHIP Antibody (960-1040 aa) LS-C386057

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (960-1040 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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INPP5D / SHIP1 / SHIP Antibody LS-C826027

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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INPP5D / SHIP1 / SHIP Antibody (1110-1190 aa, C-terminal) LS-C386059

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (1110-1190 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1021) LS-C822077

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (pTyr1021) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

INPP5D / SHIP1 / SHIP Antibody (p1020) LS-C822074

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (p1020) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

INPP5D / SHIP1 / SHIP Antibody (960-1040 aa) LS-C380925

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (960-1040 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

INPP5D / SHIP1 / SHIP Antibody (aa987-1036) LS-C117781

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (aa987-1036) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1021) LS-C199568

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (pTyr1021) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1020) LS-C750584

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (pTyr1020) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

Select

INPP5D / SHIP1 / SHIP Antibody (aa770-796) LS-C97337

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (aa770-796) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

INPP5D / SHIP1 / SHIP Antibody (C-Terminus) LS-C352374

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

INPP5D / SHIP1 / SHIP Antibody (C-Terminus) LS-C356127

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$315

Select

INPP5D / SHIP1 / SHIP Antibody (C-Terminus) LS-C368981

Antibody:

INPP5D / SHIP1 / SHIP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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