Detects hemagglutinin H5 from the Influenza A virus H5N1. Influenza A belongs to the Orthomyxoviridae family, and is a negative sense single-stranded RNA virus which results in respiratory disease. Hemagglutinin is an antigenic glycoprotein which allows viral attachment and entry into the cell. Sixteen subtypes of hemagglutinin (H1-H16) have been described, of which H1, H2 and H3 infect humans. H5 and H7 normally result in avian disease, with some highly pathogenic H5N1 strains causing 100% mortality in poultry. H5N1 has in some cases mutated to infect humans, with 60% mortality. Hemagglutinin is one of the most medically relevant antigens on influenza as it is a target for antiviral drugs and antibodies. May be used to detect Influenza H5N1 in ELISA assays.
ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with LS-C58231
as a capture reagent.
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
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