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ILT2 / CD85
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
| Gene Name: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
| Synonyms: | LILRB1, CD85, CD85j antigen, CD85J, Ig-like transcript 2, Leukocyte Ig-like receptor-1, LIR-1, LIR1, ILT-2, MIR-7, MIR7, ILT2 |
| Target Sequences: | Q8NHL6 Q8NHL6 |
Publications (2)
1
Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X. Levy E, Reger R, Segerberg F, Lambert M, Leijonhufvud C, Baumer Y, Carlsten M, Childs R. Frontiers in immunology. 2019 June;10: [Full Text Article]
[PubMed:31231387]
[PMC:PMC6560173]
2
LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity. Caroline Leijonhufvud, Robert Reger, Filip Segerberg, Jakob Theorell, Heinrich Schlums, Yenan T Bryceson, Richard W Childs, Mattias Carlsten. Clinical & translational immunology. 2021 October;10:e1346. [Full Text Article]
[PubMed:34631057]
[PMC:PMC8491220]
Related Antibodies: LS-C107050.
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ILT2 / CD85 Mouse anti-Human Monoclonal (APC) (HP-F1) Antibody
Human
Flo
APC Conjugated
25 Tests/$331; 100 Tests/$504
ILT2 / CD85 Mouse anti-Human Monoclonal (GHI/75) Antibody
Human
Flo, Func, IP, WB
Unconjugated
0.1 mg/$302
ILT2 / CD85 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa223-410) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
ILT2 / CD85 Mouse anti-Human Monoclonal (CF) Antibody
Human
Flo
CF Conjugated
100 Tests/$694
ILT2 / CD85 Mouse anti-Human Monoclonal (Low Endotoxin) (GHI/75) Antibody
Human
Flo, Func, IP, WB
Unconjugated, Low Endotoxin
0.1 mg/$302
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) Antibody
Human
WB
Unconjugated
400 µl/$393
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.24kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ILT2 / CD85 Mouse anti-Human Monoclonal (PE) (GHI/75) Antibody
Human
Flo, Func, IP, WB
PE Conjugated
100 Tests/$365
ILT2 / CD85 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ILT2 / CD85 Mouse anti-Human Monoclonal (aa1-523) (Azide-free) Antibody
Human
ELISA, WB
Unconjugated, Azide-free
100 µg/$705
ILT2 / CD85 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ILT2 / CD85 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
ILT2 / CD85 Rabbit anti-Human Polyclonal (aa345-374) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
ILT2 / CD85 Rabbit anti-Human Polyclonal (21-70 aa, N-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ILT2 / CD85 Mouse anti-Human Monoclonal Antibody
Human
Flo
Unconjugated
100 µl/$412
ILT2 / CD85 Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
ILT2 / CD85 Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$832
ILT2 / CD85 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$801
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