Human IL6ST / CD130 / gp130
IL6ST | CD130 | CD130 antigen | IL-6R subunit beta | IL-6 receptor subunit beta | Membrane glycoprotein gp130 | Membrane glycoprotein 130 | IL-6RB | CDW130 | gp130 | IL-6R-beta
(tested or 100% immunogen sequence identity)
Ion exchange chromatography
Natural soluble gp130 receptor.
Recognizes soluble and membrane bound gp130 receptor, also known as CD130, Interleukin-6 receptor subunit beta, Oncostatin-M receptor subunit alpha or Interleukin-6 signal transducer. CD130 is a 918 amino acid, ~130 kD single pass type-1 transmembrane glycoprotein containing a single and multiple domains. CD130 can be cleaved to form a monomeric soluble ~100 kD form of the receptor detectable in plasma and other biologic fluids where it acts as an IL-6 antagonist. Binds to an epitope dependent at least partially on the presence of the Ig-like domain. Has been reported to block receptor activity and inhibit IL-6 induced proliferation of XG1 cells and IL-27 mediated proliferation of naive CD4+ T cells,.