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IL2RA / CD25
interleukin 2 receptor, alpha
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
| Gene Name: | interleukin 2 receptor, alpha |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL2RA, CD25 antigen, CD25, IDDM10, IL-2 receptor subunit alpha, IL2R, Interleukin 2 receptor, alpha, IL-2-RA, IL2-RA, TCGFR, IL-2R subunit alpha, p55, TAC antigen |
| Target Sequences: | NM_000417 NP_000408.1 P01589 |
Publications (3)
1
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89.
[PubMed:19849846]
[PMC:PMC2770477]
Related Antibodies: LS-C40810.
2
A Myristoylated Alanine-Rich C Kinase Substrate-Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils. Li J, D'Annibale-Tolhurst MA, Adler KB, Fang S, Yin Q, Birkenheuer AJ, Levy MG, Jones SL, Sung EJ, Hawkins EC, Yoder JA, Nordone SK. American journal of respiratory cell and molecular biology. 2013 48:314-21.
[PubMed:23221047]
Related Antibodies: LS-C40810.
3
Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li XN, McNall-Knapp RY, Fung KM, Towner RA. PloS one. 2015 10:e0134276. (WB, Flo; Human, Rat)
[Full Text Article]
[PubMed:26248280]
[PMC:PMC4527837]
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IL2RA / CD25 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$460
IL2RA / CD25 Mouse anti-Human Monoclonal (aa34-139) (1B5D12) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
IL2RA / CD25 Mouse anti-Rat Monoclonal (OX-39) Antibody
Rat
ELISA, Flo, IHC, IHC-Fr, IHC-P, IP
Unconjugated
0.1 mg/$395
IL2RA / CD25 Mouse anti-Human Monoclonal (Azide-free) (7G7B6) Antibody
Human
Flo, IHC
Unconjugated, Azide-free
100 µg/$411
IL2RA / CD25 Mouse anti-Human Monoclonal (Concentrated) (4C9) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$1,098
IL2RA / CD25 Rabbit anti-Human Polyclonal (aa223-272) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL2RA / CD25 Mouse anti-Human Monoclonal (4C9) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$358
IL2RA / CD25 Rabbit anti-Human Polyclonal (pSer268) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IL2RA / CD25 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC-P, WB
Unconjugated
100 µl/$299
IL2RA / CD25 Rat anti-Mouse Monoclonal (PE, Cy7) (7D4) Antibody
Mouse
Flo
PE, Cy7 Conjugated
0.1 mg/$404
IL2RA / CD25 Mouse anti-Human Monoclonal (BC96) Antibody
Human
Flo
Unconjugated
100 µg/$239
IL2RA / CD25 Mouse anti-Human Monoclonal (Biotin) (7G7B6) Antibody
Human
Flo, IHC
Biotin Conjugated
100 µg/$446
IL2RA / CD25 Mouse anti-Human Monoclonal (FITC) (7G7B6) Antibody
Human
Flo, IHC
FITC Conjugated
120 Tests/$446
Human Cells
Mouse IgG1 Fc
Less than 1.0 EU/µg protein (determined by LAL method).
55.5kD
10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157
IL2RA / CD25 Human anti-Human Recombinant Monoclonal (IL-2R alpha (CD25)) (Basiliximab) Antibody
Human, Monkey-Cynomolgus, Monkey-Rhesus
Block, Flo, IF, IHC, WB
Unconjugated
0.2 mg/$540
IL2RA / CD25 Rabbit anti-Human Recombinant Monoclonal (IL-2R alpha (CD25)) (Basiliximab) Antibody
Human, Monkey-Cynomolgus, Monkey-Rhesus
Block, Flo, IF, IHC, WB
Unconjugated
0.2 mg/$540
IL2RA / CD25 Rat anti-Mouse Monoclonal Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 250 µg/$755
HEK 293 Cells
His, N-Terminal
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
42 kDa (SDS-PAGE)
50 µg/$355; 10 µg/$273; 1 mg/$1,656
IL2RA / CD25 Mouse anti-Human Monoclonal (B489) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
0.5 ml/$328
IL2RA / CD25 Rat anti-Mouse Monoclonal (G1/G1-4) Antibody
Mouse
Flo, IHC
Unconjugated
500 µg/$587
IL2RA / CD25 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL2RA / CD25 Rabbit anti-Human Polyclonal (aa250-272) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL2RA / CD25 Rabbit anti-Human Polyclonal (aa39-57) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IL2RA / CD25 Mouse anti-Rat Monoclonal (APC) (OX-39) Antibody
Rat
Flo, IHC, IHC-Fr
APC Conjugated
100 µg/$398
IL2RA / CD25 Rabbit anti-Mouse Polyclonal (aa22-235) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
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of 356
product results
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