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IL12A / p35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
IL12A / p35 is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
| Gene Name: | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL12A, CLMF p35, IL-12, subunit p35, IL-12A, Interleukin-12 alpha chain, NFSK, p35, Interleukin-12 subunit alpha, NKSF1, CLMF, IL-12 subunit p35, IL35 subunit, Interleukin 12, p35 |
| Target Sequences: | NM_000882 NP_000873.2 P29459 |
Publications (1)
1
IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB, Bar-Sagi D. Cancer discovery. 2016 6:247-55. (WB; Human)
[Full Text Article]
[PubMed:26715643]
[PMC:PMC5709038]
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IL12A / p35 Rabbit anti-Human Polyclonal (aa168-195) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
IL12A / p35 Rabbit anti-Human Polyclonal (aa16-65) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
IL12A / p35 Goat anti-Human Polyclonal Antibody
Dog, Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$441
IL12A / p35 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IL12A / p35 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
IL12A / p35 Mouse anti-Human Monoclonal (aa23-219) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$305; 200 µl/$345; 500 µl/$479; 1 ml/$547; 2 ml/$725; 5 ml/$1,192
E. coli
His, N-Terminal
25.4 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
IL12A / p35 Rabbit anti-Human Polyclonal (aa168-195) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Sandwich
96-Well Strip Plate
Human
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$826
IL12A / p35 Rabbit anti-Human Polyclonal (Internal) Antibody
Dog, Sheep, Bovine, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL12A / p35 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL12A / p35 Mouse anti-Human Monoclonal (1A6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
IL12A / p35 Rat anti-Mouse Monoclonal (aa23-215) (11n102) Antibody
Mouse
IHC
Unconjugated
100 µg/$896
IL12A / p35 Mouse anti-Human Monoclonal Antibody
Mouse, Human
WB
Unconjugated
100 µl/$305; 200 µl/$345; 500 µl/$479; 1 ml/$547; 2 ml/$725; 5 ml/$1,192
IL12A / p35 Rabbit anti-Mouse Polyclonal (aa23-215) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
IL12A / p35 Rabbit anti-Mouse Polyclonal (aa23-215) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248
IL12A / p35 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$314; 200 µl/$359; 500 µl/$506; 1 ml/$580; 2 ml/$797; 5 ml/$1,295
IL12A / p35 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
20 µl/$256; 100 µl/$412
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Dog
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
Mammalian Cells
None
Biologically active
75 kDa
10 µg/$388; 500 µg/$3,025; 100 µg/$1,466
IL12A / p35 Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IL12A / p35 Mouse anti-Human Monoclonal (aa57-253) (OTI2A8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
IL12A / p35 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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