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IL-1B / IL-1 Beta
interleukin 1, beta
IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
| Gene Name: | interleukin 1, beta |
| Family/Subfamily: | IL-1 , not assigned-IL-1 |
| Synonyms: | IL1B, IL-1B, IL-1 beta, IL1-BETA, Preinterleukin 1 beta, Pro-interleukin-1-beta, Catabolin, IL-1, IL1F2, Interleukin 1, beta, Interleukin-1 beta |
| Target Sequences: | NM_000576 NP_000567.1 P01584 |
Publications (16)
1
Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4’-geranyloxyferulic acid. Takuji Tanaka, Mariangela B.M. de Azevedo, Nelson Dura´n, Joel B. Alderete, Francesco Epifano, Salvatore Genovese, Mayu Tanaka, Takahiro Tanaka, Massimo Curini. International journal of cancer. Journal international du cancer. 2010 126:830-40. (IHC-P; Mouse)
[Full Text Article]
[PubMed:19688830]
2
Trimeric form of intracellular ATP synthase subunit of Aggregatibacter actinomycetemcomitans binds human interleukin-1. Paino A, Tuominen H, Jskelinen M, Alanko J, Nuutila J, Asikainen SE, Pelliniemi LJ, Pllnen MT, Chen C, Ihalin R. PloS one. 2011 6:e18929.
[PubMed:21533109]
[PMC:PMC3078924]
3
Interleukin-1 is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids. Paino A, Lohermaa E, Sormunen R, Tuominen H, Korhonen J, Pllnen MT, Ihalin R. Cytokine. 2012 60:565-74. (IHC, EM; Bacteria)
[PubMed:22898394]
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IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Human, Primate
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, Neut, RIA, WB
Unconjugated
1 mg/$1,225
IL-1B / IL-1 Beta Mouse anti-Human Monoclonal (OTI3E1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
IL-1B / IL-1 Beta Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL-1B / IL-1 Beta Rabbit anti-Sheep Polyclonal (Serum) Antibody
Sheep
ELISA, WB
Unconjugated, Serum
0.1 ml/$570
IL-1B / IL-1 Beta Mouse anti-Human Monoclonal (3A6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL-1B / IL-1 Beta Rabbit anti-Human Polyclonal (aa148-174) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
IL-1B / IL-1 Beta Mouse anti-Sheep Monoclonal (ID4) Antibody
Goat, Sheep, Bovine
ELISA, Flo, IHC, IHC-Fr
Unconjugated
50 µg/$463; 250 µg/$958
IL-1B / IL-1 Beta Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL-1B / IL-1 Beta Mouse anti-Human Monoclonal (CRM56) Antibody
Human
ELISA, Flo, Neut
Unconjugated
500 µg/$398
IL-1B / IL-1 Beta Mouse anti-Pig Monoclonal (Azide-free) (DF8) Antibody
Pig
WB
Unconjugated, Azide-free
250 µg/$786; 500 µg/$1,256
IL-1B / IL-1 Beta Guinea pig anti-Rabbit Polyclonal (aa118-268) Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$483; 1 ml/$551; 2 ml/$734; 5 ml/$1,201
Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$685
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
17.3 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
Sandwich
96-Well Microplate
Mouse
2.743 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.5 kDa
2 µg/$268; 10 µg/$349
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$573
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$617
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$561
Sandwich
96-Well Strip Plate
Guinea pig
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$685
Sandwich
96-Well Strip Plate
Dog
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$685
Sandwich
96-Well Strip Plate
Chicken
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
Sandwich
96-Well Strip Plate
Pig
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$573
Sandwich
96-Well Strip Plate
Rabbit
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$651
Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$889
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