Chicken IL-1B / IL-1 Beta
(tested or 100% immunogen sequence identity)
Recombinant chicken IL-1.
Recognizes chicken Interleukin 1 beta (chIL-1beta), which shares homology with mammalian IL-1beta. IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Chicken models indicate physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica. Neutralizes chicken IL-1 beta.
Western Blot: LS-C43116 detects a band of approximately 29kD in HD-11 cell lysates transfected with chIL-1. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Store at 4°C or -20°C. Avoid freeze-thaw cycles.