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IHCPlus™ SLC2A4 / GLUT‑4 Antibody Polyclonal IHC LS‑B26

Catalog Number Size Price
LS-B26-50 50 µl (5 mg/ml) $485 
Anti-SLC2A4 / GLUT4 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

IHCPlus™ SLC2A4 / GLUT‑4 Antibody Polyclonal IHC LS‑B26

Note: This antibody replaces LS-C11345
Antibody:
Rabbit Polyclonal to Human SLC2A4 / GLUT-4
Application:
IHC, IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$485 
LS-B26-50
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human SLC2A4 / GLUT-4
Application:
IHC, IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
GLUT-4 antibody LS-B26 is an unconjugated rabbit polyclonal antibody to human GLUT-4 (SLC2A4 ). Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Target
Human SLC2A4 / GLUT-4
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Non-Reactivity
Pig
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 20 µg/ml)
  • IHC - Frozen
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter  conjugated to keyhole limpet hemocyanin.
Specificity
Recognizes human Solute carrier family 2, facilitated glucose transporter member 4, also known as glucose transporter 4 or GLUT4. GLUT4 is a 509 amino acid ~50 kD multi-pass transmembrane protein located primarily in the perinuclear region and is translocated to the plasma membrane where it is rapidly reinternalized. Does not react with HEP G2 type glucose transporter in human erythrocytes, rat brain or other tissues that do not exhibit sensitivity to insulin. GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
Usage
Immunohistochemistry: LS-B26 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B26 was determined to be 10-20 ug/ml.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SLC2A4 / GLUT-4
P14672 NM_001042 NP_001033.1

Validation

Anti-SLC2A4 / GLUT4 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
IHC Validated
Anti-SLC2A4 / GLUT4 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Anti-SLC2A4 / GLUT4 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

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Requested From: United States
Date Requested: 9/23/2019