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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B6298-50 50 µg (0.5 mg/ml) $425 
IVL / Involucrin Antibody - Anti-IVL / Involucrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC‑plus™ Monoclonal Mouse anti‑Human IVL / Involucrin Antibody (clone SY5, IHC, WB) LS‑B6298

IHC‑plus™ Monoclonal Mouse anti‑Human IVL / Involucrin Antibody (clone SY5, IHC, WB) LS‑B6298

Note: This antibody replaces LS-C11369
Antibody:
IVL / Involucrin Mouse anti-Human Monoclonal (SY5) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB, IP, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425
LS-B6298-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
IVL / Involucrin Mouse anti-Human Monoclonal (SY5) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB, IP, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Involucrin antibody LS-B6298 is an unconjugated mouse monoclonal antibody to human Involucrin (IVL). Validated for ELISA, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
Target
Human IVL / Involucrin
Synonyms
IVL | Involucrin
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Non-Reactivity
Mouse
Clonality
IgG1 Monoclonal
Clone
SY5
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Immunogen
Native, from keratinocytes.
Specificity
Recognizes human involucrin, a 585 amino acid soluble protein encoded by the IVL gene and expressed in epidermal keratinocytes as they tend towards terminal differentiation. Involucrin is produced in the stratum spinosum initially in the cell cytosol from where it moves to the cell membrane, associates with transglutaminase and becomes cross-linked to membrane proteins, offering structural support to the cell and forming a stable envelope below the plasma membrane. Recognizes an epitope between residues 421-568 of human involucrin. Involucrin expression is seen in the normal granular cells of the epidermis associated with the plasma membrane during the early phase of cornified envelope maturation and expression is increased in psoriatic epidermis with abnormal cornified envelope maturation. Involucrin staining is also maintained, associated with the cornified envelope in epidermolytic hyperkeratosis, a condition associated with mutations to mutations in genes coding for cytokeratins 1 and 10.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • Western blot
  • Immunoprecipitation
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About IVL / Involucrin
P07476 NM_005547 NP_005538.2

Validation

IVL / Involucrin Antibody - Anti-IVL / Involucrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-IVL / Involucrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-IVL / Involucrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LSBio Ratings

IHC-plus™ IVL / Involucrin Antibody (clone SY5) for IHC, WB/Western, IP, ELISA LS-B6298 has an LSBio Rating of
Laboratory Validation Score (4)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 12/3/2020