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| Catalog Number | Size | Price |
|---|---|---|
| LS-A307-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human GPR12 Antibody (Extracellular Domain, IHC) LS‑A307
PathPlus™ Polyclonal Rabbit anti‑Human GPR12 Antibody (Extracellular Domain, IHC) LS‑A307
Antibody:
GPR12 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPR12 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
G protein-coupled receptor 12 (GPR12) is a constitutively active Lysophospholipid/Lysosphingolipid receptor. It promotes neurite outgrowth and blocks myelin inhibition in neurons, and it also stimulates cyclic AMP production. In immunohistochemistry, GPR12 has highest membranous positivity in the basal ganglia, cerebellum and cerebral cortex in the brain, and it is found at moderate to low levels throughout the nervous system. It has additional positivity in the salivary gland, skin, and breast, and potentially at low levels in other tissues throughout the body.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR12
Synonyms
GPR12 | G protein-coupled receptor 12 | G-protein coupled receptor 12 | GPCR12 | GPCR21
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Dog, Chicken, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from 2nd extracellular domain of human GPR12 / GPCR12. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Horse, Rabbit, Pig (100%); Monkey, Dog, Bat, Opossum, Turkey, Chicken, Xenopus (93%); Platypus, Pufferfish (87%); Stickleback (80%).
Epitope
Extracellular Domain
Specificity
Human GPR12 / GPCR12. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR6 (53%).
Applications
- IHC
- IHC - Paraffin (1.2 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPR12
Validation
Skin, melanoma
Skin, melanoma
Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR12 / GPCR12 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Brain, cortex, neuron
Brain, cortex, neuron
Pancreas, carcinoma
Pancreas, carcinoma
See More About...
LSBio Ratings
PathPlus™ GPR12 Antibody (Extracellular Domain) for IHC LS-A307 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
