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| Catalog Number | Size | Price |
|---|---|---|
| LS-A1205-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human GLP1R / GLP‑1 Receptor Antibody (N‑Terminus, IHC, IF, WB) LS‑A1205
PathPlus™ Polyclonal Rabbit anti‑Human GLP1R / GLP‑1 Receptor Antibody (N‑Terminus, IHC, IF, WB) LS‑A1205
Antibody:
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Overview
Antibody:
GLP1R / GLP-1 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
Glucagon-like peptide 1 receptor (GLP1R) is a receptor for glucagon and glucagon-like peptide-1 (GLP1). It is involved in insulin synthesis and release, blood glucose homeostasis, appetite control, memory and learning, as well as control of breathing and heart rate. Stimulation of GLP1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). In immunohistochemistry, GLP1R has highest membranous positivity on pancreatic beta cells, it is expressed on neurons in the brain and nervous system, and it is also found in the stomach, salivary gland, heart muscle, gallbladder, salivary gland, duodenum and at low levels in a few other tissues.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GLP1R / GLP-1 Receptor
Synonyms
GLP1R | GLP-1-R | GLP-1 receptor | GLP-1R | GLP-I receptor | Glp1 receptor
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human GLP1R. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Mouse, Bovine, Hamster, Elephant, Rabbit, Pig (94%); Rat, Dog, Bat, Panda (88%).
Epitope
N-Terminus
Specificity
Human GLP1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RUSC2 (44%).
Applications
- IHC
- IHC - Paraffin (15 - 20 µg/ml)
- Immunofluorescence
- Western blot
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GLP1R / GLP-1 Receptor
Validation
Adrenal
Adrenal
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Lung, small cell carcinoma
Lung, small cell carcinoma
Brain, Cortex, Neurons
Brain, Cortex, Neurons
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R antibody IHC staining of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R antibody IHC staining of human pancreas, islet of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP1R/GLP-1R/GLP-1 Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ GLP1R / GLP-1 Receptor Antibody (N-Terminus) for IHC, IF/Immunofluorescence, WB/Western LS-A1205 has an LSBio Rating of
Publications (4.7)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (8)
Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J. Diabetes. 2011 60:2397-406. (IHC-Fr; Mouse)
Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. The Journal of clinical investigation. 2012 122:388-402. (IHC; Mouse)
GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE–/– Mice. Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, Brown TJ, Streutker C, Holland D, Cao X, Baggio LL, Drucker DJ. Endocrinology. 2013 154:127-39. (WB; Mouse, Hamster)
The Glucagon-Like Peptide-1 Receptor—or Not?. Pyke C, Knudsen LB. Endocrinology. 2013 154:8-Apr. (IHC-P; Human)
Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H. Diabetes. 2010 Apr;59:1030-7.
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Noyan-Ashraf MH, Momen MA, Ban K, Sadi AM, Zhou YQ, Riazi AM, Baggio LL, Henkelman RM, Husain M, Drucker DJ. Diabetes. 2009 Apr;58:975-83.
IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Mita T, Azuma K, Goto H, Jin WL, Arakawa M, Nomiyama T, Suzuki R, Kubota N, Tobe K, Kadowaki T, Fujitani Y, Hirose T, Kawamori R, Watada H. Biochemical and biophysical research communications. 2011 Dec;415:545-50.
Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro. Baldassano S, Wang GD, Mul[Character e8] F, Wood JD. American journal of physiology. Gastrointestinal and liver physiology. 2012 Feb;302:G352-8.
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Featured Products
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Immunofluorescence
Species:
Mouse, Human, Rat
Applications:
Western blot, ELISA
Species:
Human, Monkey, Mouse, Bat, Dog, Hamster, Horse, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Immunofluorescence
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/16/2024
Date Requested: 4/16/2024
