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| Catalog Number | Size | Price |
|---|---|---|
| LS-A7131-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human ESRRB / ERR Beta Antibody (Ligand‑binding Domain, IHC) LS‑A7131
PathPlus™ Polyclonal Rabbit anti‑Human ESRRB / ERR Beta Antibody (Ligand‑binding Domain, IHC) LS‑A7131
Antibody:
ESRRB / ERR Beta Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bovine, Dog, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
ESRRB / ERR Beta Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bovine, Dog, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development. ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human ESRRB / ERR Beta
Synonyms
ESRRB | DFNB35 | ERRb | ERRbeta-2 | ESRL2 | Estrogen receptor-like 2 | ERR-beta | ERRB2 | ERRbeta | NR3B2 | Nuclear receptor ERRB2 | Orphan nuclear receptor | ERR beta-2 | ERR2 | Estrogen-related receptor 2 | Estrogen-related receptor beta | Steroid hormone receptor ERR2
Host
Rabbit
Reactivity
Human, Monkey, Bovine, Dog, Hamster, Horse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Chicken (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from ligand-binding domain of human ESRRB. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Hamster, Panda, Dog, Bovine, Horse, Rabbit, Pig, Opossum (100%); Mouse, Rat, Elephant, Turkey, Chicken, Lizard (93%); Bat (87%); Stickleback, Medaka, Pufferfish, Zebrafish (80%).
Epitope
Ligand-binding Domain
Specificity
Human ESRRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ESRRG (67%).
Applications
- IHC
- IHC - Paraffin (3 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ESRRB / ERR Beta
Validation
Colon, Carcinoma
Colon, Carcinoma
Prostate, Carcinoma
Prostate, Carcinoma
Anti-ESRRB / ERR Beta antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ESRRB / ERR Beta antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ESRRB antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ESRRB antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ ESRRB / ERR Beta Antibody (Ligand-binding Domain) for IHC LS-A7131 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Hamster, Horse
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Hamster, Horse
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Horse
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/24/2024
Date Requested: 4/24/2024
