IGHM / IgM

immunoglobulin heavy constant mu

Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).

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Antibodies (29)

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IGHM / IgM (35)

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monoclonal mc (17)

polyclonal pc (8)

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Clone

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IHC-plus™ IGHM / IgM Antibody (clone 8B9D3) LS-B16340

(4.0) Rating

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (8B9D3) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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IHC-plus™ IGHM / IgM Antibody (clone 9A8A4) LS-B16341

(4.0) Rating

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (9A8A4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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IGHM / IgM Antibody (clone DA4-4, SA-DA4 or HB57) LS-C391543

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (DA4-4, SA-DA4 or HB57) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

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IGHM / IgM Antibody (clone DA4-4, SA-DA4 or HB57, Azide-free, BSA-free) LS-C391550

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (Azide-free, BSA-free) (DA4-4, SA-DA4 or HB57) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-P

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

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IGHM / IgM Antibody (clone DA4-4, SA-DA4 or HB57, Ready-to-Use) LS-C391545

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (Ready-to-Use) (DA4-4, SA-DA4 or HB57) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

7 ml/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Azide-free, BSA-free
• Unconjugated, Ready-to-Use

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IGHM / IgM Antibody (clone SPM557) LS-C392235

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (SPM557) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

20 µg/$371; 100 µg/$574

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IGHM / IgM Antibody (clone SPM557, Azide-free, BSA-free) LS-C392238

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM557) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated, Azide-free, BSA-free

Price:

100 µg/$574

• Unconjugated
• Unconjugated, Azide-free, BSA-free

• Unconjugated
• Unconjugated, Azide-free, BSA-free

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IGHM / IgM Antibody (clone CM7) LS-C745828

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (CM7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC-P, WB

Format:

Unconjugated

Price:

0.25 mg/$536

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IGHM / IgM Antibody LS-C680644

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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IGHM / IgM Antibody (HRP) LS-C680646

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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IGHM / IgM Antibody (Biotin) LS-C680643

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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IGHM / IgM Antibody (FITC) LS-C680645

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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IGHM / IgM Antibody (clone 47.2.E9, FITC) LS-C746120

Antibody:

IGHM / IgM Mouse anti-Human Monoclonal (FITC) (47.2.E9) Antibody

Reactivity:

Human

Applications:

Flo, IF

Format:

FITC Conjugated

Price:

0.1 mg/$416

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IGHM / IgM Antibody LS-C666346

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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IGHM / IgM Antibody LS-C779823

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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IGHM / IgM Antibody LS-C813539

Antibody:

IGHM / IgM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IGHM / IgM Antibody LS-C664006

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581; 2 ml/$798; 5 ml/$1,296

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IGHM / IgM Antibody (HRP) LS-C707597

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$345; 200 µl/$403; 500 µl/$595; 1 ml/$742; 2 ml/$979; 5 ml/$1,684

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IGHM / IgM Antibody (Biotin) LS-C684648

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$325; 200 µl/$373; 500 µl/$536; 1 ml/$628; 2 ml/$860; 5 ml/$1,425

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IGHM / IgM Antibody (FITC) LS-C690926

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$356; 200 µl/$418; 500 µl/$638; 1 ml/$798; 2 ml/$1,035; 5 ml/$1,813

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IGHM / IgM Antibody (APC, Cy7) LS-C730660

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$521; 200 µl/$685; 500 µl/$1,198; 1 ml/$1,481; 2 ml/$2,073; 5 ml/$3,885

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IGHM / IgM Antibody (APC) LS-C738730

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$418; 200 µl/$507; 500 µl/$887; 1 ml/$1,051; 2 ml/$1,383; 5 ml/$2,591

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IGHM / IgM Antibody (Cy3) LS-C698571

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$418; 200 µl/$507; 500 µl/$887; 1 ml/$1,051; 2 ml/$1,383; 5 ml/$2,591

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IGHM / IgM Antibody (PE) LS-C721654

Antibody:

IGHM / IgM Mouse anti-Mouse Monoclonal (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$418; 200 µl/$507; 500 µl/$887; 1 ml/$1,051; 2 ml/$1,383; 5 ml/$2,591

• Unconjugated
• HRP
• Biotin
• FITC
• APC, Cy7
• APC
• Cy3
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC, Cy7
  • APC
  • Cy3
  • PE

Select

IGHM / IgM Antibody (Serum) LS-C745868

Antibody:

IGHM / IgM Goat anti-Human Polyclonal (Serum) Antibody

Reactivity:

Human

Applications:

ELISA, Turbidimetry

Format:

Unconjugated, Serum

Price:

1 ml/$320

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