Human IGFBP7 / TAF
IGFBP7 | AGM | FSTL2 | IGFBP-7v | IGFBP-rP1 | IBP-7 | Angiomodulin | RAMSVPS | MAC25 protein | PSF | TAF | Tumor-derived adhesion factor | IGF-binding protein 7 | IGFBP-7 | IGFBPRP1 | MAC25 | PGI2-stimulating factor
(tested or 100% immunogen sequence identity)
Recombinant human IGFBP-7
Recognizes human IGFBP-7 (insulin-like growth factor binding protein-7), also known as mac25, a 256 amino acid secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulin-like growth factors (IGFs), through binding to IGF-I and IGF-II. IGFBP-7 is widely expressed throughout normal tissues, but is also expressed in many tumor types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP-7 inhibits IGF-induced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.