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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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IGF2R / CD222 Antibody (phospho‑Ser2409) LS‑C199095
CD222 antibody LS-C199095 is an unconjugated rabbit polyclonal antibody to CD222 (IGF2R) from human and mouse. Validated for IHC, Peptide-ELISA and WB.
Catalog
Size
Price
LS-C199095-50
50 µl (1 mg/ml)
$265
LS-C199095-100
100 µl (1 mg/ml)
$325

Popular IGF2R / CD222 Products

Anti-IGF2R antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5653 dilution 1:100.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Immunofluorescence, Peptide Enzyme-Linked Immunosorbent Assay
Antibody
Species: Human, Non-Human Primates
Applications: Western blot, Flow Cytometry
Immunohistochemical analysis of CD222 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Bovine
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Permeabilized Peripheral Human Granulocytes stained with Mouse anti Human CD222: APC. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Rhesus monkey
Applications: Flow Cytometry
Antibody
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, ELISA

Product Description

CD222 antibody LS-C199095 is an unconjugated rabbit polyclonal antibody to CD222 (IGF2R) from human and mouse. Validated for IHC, Peptide-ELISA and WB.
About IGF2R / CD222
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. P11717 NM_000876 NP_000867.2

IGF2R Antibody, CD222 antigen Antibody, CIMPR Antibody, CI Man-6-P receptor Antibody, CI-MPR Antibody, IGF-II receptor Antibody, MPR 300 Antibody, MPR1 Antibody, MPRI Antibody, M6P-R Antibody, M6P/IGF2R Antibody, CD222 Antibody, M6P/IGF2 receptor Antibody


Specifications

Target
Human IGF2R / CD222
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:50 - 1:100)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:10000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
IGF2R / CD222 antibody was raised against synthetic peptide derived from human IGF2R around the phosphorylation site of Ser2409. (AA Range: 2381-2430)
Epitope
pSer2409
Specificity
IGF2R (Phospho-Ser2409) Antibody detects endogenous levels of IGF2R only when phosphorylated at serine2409.
Usage
Western Blot: Predicted MW 274 kDa
Presentation
PBS, pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C.
Restrictions
For research use only.

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Images

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot

Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot

Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot

Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot

Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of lysates from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is blocked with the phospho peptide.

Requested From: United States
Date Requested: 9/22/2018

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