Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
IGF2R / CD222 antibody was raised against recombinant Vaccinia virus encoding CD222.
Recognizes an epitope between domains 2 and 5 of CD222 (IGF II receptor), a 250kD ubiquitously expressed multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment; only about 5-10% is in the plasma membrane. The truncated form of the receptor (220kD) is present in human and bovine serum. Reacts with human and non-human primates.
Suitable for use in Flow cytometry and Western blot (non-reducing).
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.