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ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Name: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Synonyms: ID2, BHLHb26, Cell growth-inhibiting gene 8, ID2H, Inhibitor of differentiation 2, GIG8, Helix-loop-helix protein ID2, ID2A, Inhibitor of DNA binding 2
Target Sequences: NM_002166 NP_002157.2 Q02363

☰ Filters
Antibodies (38)
Proteins (7)
Over-Expression Lysate (2)
Primary (38)
Recombinant (5)
ID2 (45)
Human (37)
Mouse (10)
Rat (12)
Bovine (4)
Chicken (1)
Chimpanzee (3)
Gibbon (3)
Hamster (1)
Horse (4)
Macaque (1)
Monkey (3)
Orangutan (3)
IHC (13)
IHC-P (3)
WB (34)
Flo (3)
DB (2)
ELISA (11)
ICC (3)
IF (6)
Peptide-ELISA (1)
RNAi (1)
rabbit (26)
mouse (11)
goat (1)
IgG (22)
IgG1 (8)
IgG2a,k (1)
IgG2b (2)
monoclonal mc (11)
polyclonal pc (27)
2457C5a (2)
3C3 (1)
4E12G5 (3)
OTI10C3 (2)
OTI9A8 (2)
APC Conjugated (1)
Biotin Conjugated (3)
Carrier-free (2)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Preservative Free (1)
Unconjugated (27)
C-Terminus (5)
aa1-134 (2)
Amino Acid: 1-134 (1)
aa60-110 (1)
No (45)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
ID2 Antibody - IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-ID2 mouse monoclonal antibody.
Select
ID2 Mouse anti-Human Monoclonal (OTI9A8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
ID2 Antibody - IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-ID2 mouse monoclonal antibody.
Select
ID2 Mouse anti-Human Monoclonal (Carrier-free) (OTI9A8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ID2 Antibody - Human breast carcinoma stained with Anti-Id2
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ID2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC
Unconjugated
0.25 ml/$528
ID2 Antibody - IHC of paraffin-embedded breast cancer tissues using ID2 mouse monoclonal antibody with DAB staining.
Select
ID2 Mouse anti-Human Monoclonal (aa1-134) (4E12G5) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
ID2 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ID2 Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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ID2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ID2 Antibody - IHC of paraffin-embedded Carcinoma of liver using anti-ID2 mouse monoclonal antibody.
Select
ID2 Mouse anti-Human Monoclonal (OTI10C3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
ID2 Antibody - IHC of paraffin-embedded Carcinoma of liver using anti-ID2 mouse monoclonal antibody.
Select
ID2 Mouse anti-Human Monoclonal (Carrier-free) (OTI10C3) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ID2 Antibody - IHC of paraffin-embedded breast cancer tissues using ID2 mouse monoclonal antibody with DAB staining.
Select
ID2 Mouse anti-Human Monoclonal (aa1-134) (4E12G5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
ID2 Antibody - IHC image of ID2 Antibody diluted at 1:1000 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
ID2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Select
ID2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
ID2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
ID2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
ID2 Antibody - Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-ID2 mAb.
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ID2 Mouse anti-Human Monoclonal (2457C5a) Antibody
Human
DB, ICC, IF, WB
Unconjugated
100 µg/$486
ID2 Antibody - ID2 Antibody in Immunohistochemistry (IHC)
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ID2 Mouse anti-Human Monoclonal (Amino Acid: 1-134) (4E12G5) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µg/$503
ID2 Antibody - Anti-ID2 rabbit polyclonal antibody at 1:500 dilution. Lane A: HCT116 Whole Cell Lysate. Lane B: Hela Whole Cell Lysate. Lane C: 293T Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 14 kDa. Observed band size: 14 kDa.
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ID2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
ID2 Antibody - Western Blot analysis of ID2 expression in transfected 293T cell line by ID2 monoclonal antibody (M01), clone 3C3.Lane 1: ID2 transfected lysate(14.9 KDa).Lane 2: Non-transfected lysate.
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ID2 Mouse anti-Human Monoclonal (3C3) Antibody
Human
ELISA, RNAi, WB
Unconjugated
100 µg/$423
ID2 Antibody - Western blot of immunized recombinant protein using ID2 antibody.
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ID2 Mouse anti-Human Monoclonal (2457C5a) Antibody
Human
DB, ICC, WB
Unconjugated
100 µg/$965
ID2 Antibody - Immunohistochemistry of paraffin-embedded Human brain using ID2 Polyclonal Antibody at dilution of 1:30.
Select
ID2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ID2 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using ID2 Polyclonal Antibody at dilution of 1:30.
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ID2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ID2 Antibody - Western blot of ID2 pAb in extracts from 293T cells (overexpressed ID2).
Select
ID2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
ID2 Antibody - Western blot analysis of extracts of 293T cells, using ID2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
Select
ID2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
ID2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
ID2 Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$941
Select
ID2 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µg/$786
Viewing 1-25 of 45 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).