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HTR4 / 5-HT4 Receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5HT4 receptor, 5-HT4 receptor, 5-hydroxytryptamine 4 receptor, 5-hydroxytryptamine receptor 4, Serotonin 5-HT-4a receptor, Serotonin receptor 4, Cardiac 5-HT4 receptor, Serotonin 4 receptor, Serotonin 5-HT-4 receptor |
| Target Sequences: | NM_000870 NP_000861.1 Q13639 |
Publications (2)
1
Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Louiset E, Duparc C, Lenglet S, Gomez-Sanchez CE, Lefebvre H. Molecular and cellular endocrinology. 2017 February;441:99-107. (Human)
[Full Text Article]
[PubMed:27743992]
[PMC:PMC5465225]
Related Antibodies: LS-A2685.
2
Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. Le Mestre J, Duparc C, Reznik Y, Bonnet-Serrano F, Touraine P, Chabre O, Young J, Suzuki M, Sibony M, Gobet F, Stratakis CA, Raverot G, Bertherat J, Lefebvre H, Louiset E. The Journal of clinical endocrinology and metabolism. 2019 November;104:4967-4980. [Full Text Article]
[PubMed:31074783]
[PMC:PMC6937520]
Related Antibodies: LS-A2685.
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Neuroscience
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
Fast Shipping
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Dog, Guinea pig, Bovine, Hamster, Horse, Bat, Human
IHC, IHC-P
Unconjugated
50 µg/$460
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Fast Shipping
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa21-70) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa141-190) Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
WB
Unconjugated
100 µl/$424
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Asp47) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (Asn180) Antibody
Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
HTR4 / 5-HT4 Receptor Rabbit-New Zealand White anti-Human Polyclonal Antibody
Mouse, Human, Marmoset
IHC-P, WB
Unconjugated
100 µl/$393
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
HTR4 / 5-HT4 Receptor Mouse anti-Human Monoclonal (11n173) Antibody
Human
IHC
Unconjugated
100 µg/$884
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (aa131-180) Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR4 / 5-HT4 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Bovine, Pig, Human
IP, WB
Unconjugated
100 µl/$299
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