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HTR2B / 5-HT2B Receptor

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Gene Name: 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Family/Subfamily: GPCR , Serotonin
Synonyms: HTR2B, 5-HT 2B receptor, 5HT2B Receptor, 5-HT(2B), 5-HT-2B, 5-HT2b receptor, 5-HT2B, Serotonin 2b receptor, Serotonin 5-HT-2b receptor, Serotonin receptor 2B
Target Sequences: NM_000867 NP_000858.3 P41595

Publications (1)

1
Increased release of serotonin from rat primary isolated adult cardiac myofibroblasts. Emiri Tarbit, Indu Singh, Jason Nigel Peart, Svetlana Bivol, Roselyn Barbara Rose'Meyer. Scientific reports. 2021 Oct;11:20376. [Full Text Article] [PubMed:34645867] [PMC:PMC8514503] Related Antibodies: LS-B13590.

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Antibodies (29)
Proteins (4)
Primary (29)
Recombinant (4)
HTR2B / 5-HT2B Receptor (33)
Human (28)
Mouse (6)
Rat (5)
Bovine (3)
Chimpanzee (2)
Dog (3)
Guinea pig (3)
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IHC (14)
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rabbit (26)
mouse (1)
rabbit-new zealand white (2)
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monoclonal mc (1)
polyclonal pc (28)
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HRP Conjugated (1)
Unconjugated (26)
aa35-84 (4)
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30-110 aa, N-terminal (1)
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aa15-64 (1)
aa233-282 (1)
aa261-310 (1)
aa390-440 (1)
aa440-481 (1)
aa446-478 (1)
aa6-55 (1)
No (32)
Yes (1)
6His-SUMO, N-terminus (1)
GST (1)
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Human (4)
E. coli (1)
Wheat Germ Extract (3)
Purified (2)
HTR2B / 5-HT2B Receptor Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HTR2B / 5-HT2B Receptor Antibody - Anti-5HT2B Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
HTR2B / 5-HT2B Receptor Antibody - Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
HTR2B / 5-HT2B Receptor Antibody - Western blot analysis of extracts of various cell lines, using HTR2B antibody.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa15-64) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
HTR2B / 5-HT2B Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2B Antibody. The picture on the right is blocked with the synthesized peptide.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa261-310) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR2B / 5-HT2B Receptor Antibody - HTR2B / 5-HT2B antibody Western blot of 721_B cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa35-84) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
HTR2B / 5-HT2B Receptor Antibody - HTR2B / 5-HT2B antibody Western blot of 721_B cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa35-84) (FITC) Antibody
Bovine, Human
WB
FITC Conjugated
100 µl/$469
HTR2B / 5-HT2B Receptor Antibody - Western blot analysis of extracts of various cell lines, using HTR2B Antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
HTR2B / 5-HT2B Receptor Antibody - 5HT2B Receptor antibody Western blot. All lanes: Anti 5HT2B Receptor at 0.5 ug/ml. Lane 1: Rat Brain Tissue Lysate at 50 ug. Lane 2: U87 Whole Cell Lysate at 40 ug. Predicted band size: 54 kD. Observed band size: 54 kD.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa446-478) Antibody
Rabbit, Dog, Guinea pig, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
HTR2B / 5-HT2B Receptor Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using 5-HT-2B antibody.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
HTR2B / 5-HT2B Receptor Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HTR2B / 5-HT2B Receptor Antibody - Immunohistochemistry of paraffin-embedded human brain at dilution 1:100
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
HTR2B / 5-HT2B Receptor Antibody - Western blot of SR-2B antibody
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HTR2B / 5-HT2B Receptor Antibody - Peptide - + Immunofluorescence analysis of COS-7 cells, using HTR2B antibody.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
HTR2B / 5-HT2B Receptor Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using HTR2B Polyclonal Antibody at dilution of 1:20.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HTR2B / 5-HT2B Receptor Antibody - Western blot analysis of the lysates from HepG2 cells using 5-HT-2B antibody.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa233-282) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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HTR2B / 5-HT2B Receptor Rabbit-New Zealand White anti-Mouse Polyclonal (aa390-440) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
HTR2B / 5-HT2B Receptor Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using HTR2B Polyclonal Antibody at dilution of 1:60.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HTR2B / 5-HT2B Receptor Antibody - Detection limit for recombinant GST tagged HTR2B is 0.03 ng/ml as a capture antibody.
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HTR2B / 5-HT2B Receptor Mouse anti-Human Monoclonal (4A4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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HTR2B / 5-HT2B Receptor Rabbit-New Zealand White anti-Human Polyclonal (aa440-481) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
HTR2B / 5-HT2B Receptor Antibody - Western blot analysis of the lysates from COLO205 cells using HTR2B antibody.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (aa6-55) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR2B / 5-HT2B Receptor Antibody - Western blot analysis of 5-HT2B expression in HeLa (A); HT29 (B) whole cell lysates.
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IP, WB
Unconjugated
100 µl/$299
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HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$407
Viewing 1-25 of 33 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).