Human HSPA1A

Rabbit

Human, Rat, Bovine, Dog, Goat, Horse, Pig, Sheep (tested or 100% immunogen sequence identity)

Bat, Guinea pig, Rabbit (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Amino acids 577-596 (VISWLDANTLAEKDEFEHKR-human) were used as the immunogen for this HSP70 antibody. Percent identity by BLAST analysis: Human, Ferret, Sheep, Bovine, Goat, Elephant, Horse, Pig, Zebu, Dog (100%); Bat, Rabbit, Guinea pig (90%); Hamster (85%).

aa577-596

Human HSPA1A

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• IHC - Frozen (0.5 - 1 µg/ml)
• ICC (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

HSPA1 (heat shock 70kDa protein 1A) also known as HSPA1A, HSP72 or HSP70I, is a protein that in humans is encoded by the HSPA1A gene. This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. The HSPA1A gene encodes a predicted 641-amino acid protein. Shimizu et al. (1999) found that peripheral blood mononuclear cells of 18 major depression patients expressed a short HSPA1A transcript that utilized exon 1 rather than exon 2, which is found in the more common HSPA1A transcript. No protein was associated with expression of this short HSPA1A mRNA, possibly due to lack of a TATA box or loss of internal ribosome binding sites. Treatment with BGP-15, a pharmacologic inducer of HSP72 that can protect against obesity-induced insulin resistance, improved muscular architecture, strength, and contractile function in severely affected diaphragm muscles in mdx dystrophic mice.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

NCBI: NM_005345 NP_005336.3