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HSD17B12

hydroxysteroid (17-beta) dehydrogenase 12

Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.

Gene Name: hydroxysteroid (17-beta) dehydrogenase 12
Synonyms: HSD17B12, 17-beta-HSD 12, 17beta-HSD type 12, 3-ketoacyl-CoA reductase, KAR, SDR12C1, Steroid dehydrogenase homolog
Target Sequences: NM_016142 NP_057226.1 Q53GQ0

Publications (1)

1
Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production. Diane Rebourcet, Rosa Mackay, Annalucia Darbey, Michael K Curley, Anne Jørgensen, Hanne Frederiksen, Rod T Mitchell, Peter J O'Shaughnessy, Serge Nef, Lee B Smith. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 August;34:10373-10386. [Full Text Article] [PubMed:32557858] [PMC:PMC7496839] Related Antibodies: LS-B16612.

☰ Filters
Antibodies (52)
Proteins (5)
Primary (52)
Recombinant (5)
HSD17B12 (57)
Human (36)
Mouse (10)
Rat (18)
IHC (14)
IHC-P (3)
WB (52)
Flo (7)
ELISA (19)
Peptide-ELISA (1)
rabbit (45)
mouse (7)
Product Group
PathPlus Other (1)
IgG (15)
IgG2b,k (6)
monoclonal mc (6)
polyclonal pc (46)
APC (3)
APC Conjugated (5)
Azide-free (1)
Biotin Conjugated (7)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (15)
aa1-312 (16)
aa11-291 (8)
aa126-155 (7)
C-Terminus (4)
aa203-272 (1)
aa27-181 (1)
No (56)
Yes (1)
GST (1)
GST, N-terminus (1)
His (1)
His-GST (2)
Human (3)
Mouse (1)
Rat (1)
E. coli (3)
Wheat Germ Extract (2)
Purified (1)
HSD17B12 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSD17B12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
60 µl/$460
HSD17B12 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at dilution of 1:100.
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HSD17B12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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HSD17B12 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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HSD17B12 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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HSD17B12 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
HSD17B12 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HSD17B12 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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HSD17B12 Rabbit anti-Human Polyclonal (aa126-155) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
HSD17B12 Protein - 12.5% SDS-PAGE of human HSD17B12 stained with Coomassie Blue
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Wheat Germ Extract
GST
36.7 kDa
10 µg/$479; 25 µg/$670
HSD17B12 Protein - Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 By SDS-PAGE
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E. coli
His
38.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
HSD17B12 Antibody
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HSD17B12 Rabbit anti-Human Polyclonal (aa27-181) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
HSD17B12 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using HSD17B12 Polyclonal Antibody at dilution of 1:40.
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HSD17B12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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HSD17B12 Mouse anti-Human Monoclonal (aa203-272) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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HSD17B12 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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HSD17B12 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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HSD17B12 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
Select
HSD17B12 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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HSD17B12 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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HSD17B12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
HSD17B12 Antibody - Western blot analysis of HSD17B12 using A549 whole cells lysates
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HSD17B12 Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HSD17B12 Antibody - Western blot of recombinant HSD17B12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSD17B12 Rabbit anti-Mouse Polyclonal (aa1-312) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
Viewing 1-25 of 57 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).