Target
Human HLA-G
Synonyms
HLA-G | HLAG | HLA-6.0 | MHC class I antigen G | HLA G antigen
Reactivity
Human
(tested or 100% immunogen sequence identity)
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Immunogen
HLA-A2.1/human beta2-microglobulin double transgenic mice were immunized with murine L cells transfected with both human beta2-microglobulin and HLA-G.
Specificity
The antibody G233 recognizes several isoforms of HLA-G expressed in all populations of extravillous trophoblast (cell columns, interstitial trophoblast, endovascular trophoblast, placental bed giant cells). HLA-G belongs to the nonclassical MHC Class I molecules (MHC Class Ib).The antibody G233 has been found not to cross-react with any other MHC Class I antigens (HLA-A, -B, -C, -E, -F).