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Histone H3

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

Histone H3 Target Details

Target Name:

Histone H3

Publications (8)

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Molecular cell. 2009 33:417-27. (WB) [PubMed:19250903] [PMC:PMC2671231]

Epigenetic modifications induced by RGC-32 in colon cancer. Vlaicu SI, Tegla CA, Cudrici CD, Fosbrink M, Nguyen V, Azimzadeh P, Rus V, Chen H, Mircea PA, Shamsuddin A, Rus H. Experimental and molecular pathology. 2010 88:67-76. (WB) [PubMed:19883641] [PMC:PMC2815209]

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth. Peng DJ, Zeng M, Muromoto R, Matsuda T, Shimoda K, Subramaniam M, Spelsberg TC, Wei WZ, Venuprasad K. Journal of immunology (Baltimore, Md. : 1950). 2011 186:5638-47. [PubMed:21471442]

Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response. Qian Z, Xuan B, Chapa TJ, Gualberto N, Yu D. Journal of virology. 2012 86:6712-23. [PubMed:22496230] [PMC:PMC3393534]

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein. Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS. The Journal of biological chemistry. 2013 288:141-51. [PubMed:23152495] [PMC:PMC3537008]

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes. Vecchio F, Lo Buono N, Stabilini A, Nigi L, Dufort MJ, Geyer S, Rancoita PM, Cugnata F, Mandelli A, Valle A, Leete P, Mancarella F, Linsley PS, Krogvold L, Herold KC, Elding Larsson H, Richardson SJ, Morgan NG, Dahl-Jørgensen K, Sebastiani G, Dotta F, Bosi E; DRI_Biorepository Group; Type 1 Diabetes TrialNet Study Group, Battaglia M. JCI insight. 2018 September;3:pii: 122146. [Full Text Article] [PubMed:30232284] [PMC:PMC6237216] Related Antibodies: LS-C144555.

Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide in Burkholderia Persistent Infections. Micheva-Viteva SN, Ross BN, Gao J, Adikari S, Zhang P, Mourant JR, Wu TH, Werner JH, Torres AG, Hong-Geller E. Infection and immunity. 2018 December;87:pii e00592-18. [Full Text Article] [PubMed:30323029] [PMC:PMC6300628] Related Antibodies: LS-C144555.

Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy. Kenta Hirai, Daiki Ousaka, Yosuke Fukushima, Maiko Kondo, Takahiro Eitoku, Yusuke Shigemitsu, Mayuko Hara, Kenji Baba, Tatsuo Iwasaki, Shingo Kasahara, Shinichi Ohtsuki, Hidemasa Oh. Science translational medicine. 2020 December;12: [Full Text Article] [PubMed:33298561] Related Antibodies: LS-C353149.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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