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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Histone Antibody (clone 1415‑1, Ready‑to‑Use) LS‑C390267
Histone antibody LS-C390267 is an unconjugated mouse monoclonal antibody to Histone from human, mouse and rat. Validated for Flow, IF and IHC.
Catalog
Size
Price
LS-C390267-7000
7000 µl
$395
Description
Histone antibody LS-C390267 is an unconjugated mouse monoclonal antibody to Histone from human, mouse and rat. Validated for Flow, IF and IHC.
Target
Human Histone
Host
Mouse
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG2a,k Monoclonal [1415-1]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Ready-to-Use. Also available Unmodified or Azide-free.
Applications
  • IHC
  • IHC - Paraffin (1:1)
  • Immunofluorescence
  • Flow Cytometry
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Histone antibody was raised against nuclei of human leukemia biopsy cells were used as the immunogen for the Histone antibody.
Specificity
Human Histone
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer. formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation. Optimal dilution of the Histone antibody should be determined by the researcher. Staining of formalin/paraffin tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Presentation
PBS, 0.01% BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only.

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Images

Immunohistochemistry

FFPE human pancreas tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human pancreas tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human angiosarcoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human angiosarcoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human pancreas tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human pancreas tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human angiosarcoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human angiosarcoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human pancreas tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human pancreas tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human angiosarcoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human angiosarcoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human pancreas tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human pancreas tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human ovarian carcinoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

FFPE human angiosarcoma tested with Histone H1 antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
FFPE human angiosarcoma tested with Histone H1 antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with Histone antibody (1415-1). This image was taken for the unmodified form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 12/19/2018
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