Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

HBXIP

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms: LAMTOR5, HBXIP, XIP
Target Sequences: NM_006402 NP_006393.2 O43504

Publications (1)

1
miRNA-548p suppresses hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein hepatitis B x-interacting protein. Xiu-Mei Hu, Xiao-Hui Yan, Yan-Wei Hu, Jin-Lan Huang, Shun-Wang Cao, Ting-Yu Ren, Yue-Ting Tang, Li Lin, Lei Zheng, Qian Wang. Hepatology research : the official journal of the Japan Society of Hepatology. 2016 July;46:804-15. [Full Text Article] [PubMed:26583881] Related Antibodies: LS-C111379.

☰ Filters
Antibodies (18)
Proteins (6)
ELISA Kits (5)
Custom (3)
Over-Expression Lysate (2)
Primary (18)
Recombinant (4)
Sandwich (2)
HBXIP (29)
Human (20)
Mouse (5)
Rat (1)
Pig (1)
IHC (5)
IHC-P (2)
WB (15)
ELISA (5)
Peptide-ELISA (1)
rabbit (18)
Product Group
IHCPlus (1)
IgG (12)
polyclonal pc (18)
96-Well Strip Plate (5)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (10)
N-Terminus (4)
No (28)
Yes (1)
Plasma (2)
Serum (2)
Tissue Homogenates (1)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
HBXIP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
HBXIP Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
HBXIP Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
HBXIP Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Select
HBXIP Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
HBXIP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
HBXIP Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
HBXIP Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
Select
HBXIP Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
HBXIP Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µl/$460
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HBXIP Antibody - Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
HBXIP Antibody - 1:100 staining human lymph carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HBXIP Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using LAMTOR5 Polyclonal Antibody at dilution of 1:55(×200)
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HBXIP Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer tissue  using LAMTOR5 Polyclonal Antibody at dilution of 1:35(×200)
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
HBXIP Antibody
Select
HBXIP Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
HBXIP Protein - Purified recombinant protein LAMTOR5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
18 kDa
20 µg/$1,107
HBXIP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HBXIP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
18 kDa
20 µg/$150
HBXIP ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
HBXIP ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
HBXIP ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
HBXIP Protein - 12.5% SDS-PAGE of human HBXIP stained with Coomassie Blue
Select
Wheat Germ Extract
GST
35.75 kDa
10 µg/$479; 25 µg/$670
Viewing 1-25 of 29 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).