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HBEGF / HB EGF

heparin-binding EGF-like growth factor

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Gene Name: heparin-binding EGF-like growth factor
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: HBEGF, Dtr, DTS, DTSF, HEGFL, Diphtheria Toxin Receptor
Target Sequences: NM_001945 NP_001936.1 Q99075

Publications (1)

1
Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis. S Kim, M J Graham, R G Lee, L Yang, S Kim, V Subramanian, J D Layne, L Cai, R E Temel, D Shih, A J Lusis, J A Berliner, S Lee. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2019 March;29:306-315. [Full Text Article] [PubMed:30738642] [PMC:PMC6452438]

☰ Filters
Antibodies (47)
ELISA Kits (22)
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Primary (47)
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HBEGF / HB EGF (84)
Human (46)
Mouse (21)
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rabbit (36)
mouse (11)
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HBEGF / HB EGF Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HBEGF / HB EGF Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
HBEGF / HB EGF Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
HBEGF / HB EGF Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Bovine, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
12-14 kDa (SDS-PAGE)
5 µg/$239; 25 µg/$286; 1 mg/$1,148
HBEGF / HB EGF ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$705
HBEGF / HB EGF ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$741
HBEGF / HB EGF Antibody - HBEGF Antibody western blot of K562 cell line lysates (35 ug/lane). The HBEGF antibody detected the HBEGF protein (arrow).
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HBEGF / HB EGF Rabbit anti-Human Polyclonal (aa68-96) Antibody
Human
WB
Unconjugated
400 µl/$393
HBEGF / HB EGF ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$646
HBEGF / HB EGF Antibody - Western Blot; Sample: Recombinant HBEGF, Human.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal (aa21-160) Antibody
Human
WB
Unconjugated
100 µl/$289; 200 µl/$323; 500 µl/$435; 1 ml/$491; 2 ml/$605; 5 ml/$1,045
HBEGF / HB EGF ELISA Kit
Select
Sandwich
96-Well Microplate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
HBEGF / HB EGF ELISA Kit
Select
Sandwich
96-Well Microplate
Human
20 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$840
HBEGF / HB EGF Antibody - IHC image of HBEGF Antibody diluted at 1:100 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
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HBEGF / HB EGF Mouse anti-Human Monoclonal (aa63-148) Antibody
Human
ELISA, Neut, WB
Unconjugated
100 µg/$930
HBEGF / HB EGF Antibody - Western blot of recombinant HBEGF.
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HBEGF / HB EGF Rabbit anti-Mouse Polyclonal (aa25-160) Antibody
Mouse
WB
Unconjugated
100 µl/$291; 200 µl/$326; 500 µl/$441; 1 ml/$499; 2 ml/$622; 5 ml/$1,067
HBEGF / HB EGF Antibody - Western blot of recombinant HBEGF.
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HBEGF / HB EGF Rabbit anti-Mouse Polyclonal (aa25-160) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$372; 200 µl/$441; 500 µl/$709; 1 ml/$869; 2 ml/$1,118; 5 ml/$2,017
HBEGF / HB EGF Antibody - Western blot of recombinant HBEGF.
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HBEGF / HB EGF Rabbit anti-Mouse Polyclonal (aa25-160) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$372; 200 µl/$441; 500 µl/$709; 1 ml/$869; 2 ml/$1,118; 5 ml/$2,017
HBEGF / HB EGF ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
HBEGF / HB EGF ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.81 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
14 kDa (SDS-PAGE)
50 µg/$300; 10 µg/$253; 1 mg/$1,148
HBEGF / HB EGF ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
1.37 - 1000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$990
HBEGF / HB EGF Antibody - Western blot analysis of extracts of various cell lines, using HBEGF antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
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HBEGF / HB EGF Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
HBEGF / HB EGF Rabbit anti-Human Polyclonal (aa68-96) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
HBEGF / HB EGF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
HBEGF / HB EGF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25 of 84 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).